Assay Detail
Functional
CHEMBL4151746
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell proliferation in RPMI containing 10% FBS incubated for 5 days by Cell-titer-Glo assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 9.37 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164869 | — | — | 1 | 10.00 |
| CHEMBL4168008 | — | — | 1 | 10.00 |
| CHEMBL4159755 | — | — | 1 | 10.00 |
| CHEMBL4164133 | — | — | 1 | 10.00 |
| CHEMBL4171078 | — | — | 1 | 9.70 |
| CHEMBL4161695 | — | — | 1 | 9.70 |
| CHEMBL4163162 | — | — | 1 | 9.70 |
| CHEMBL4175179 | — | — | 1 | 9.70 |
| CHEMBL4161455 | — | — | 1 | 9.70 |
| CHEMBL4176563 | — | — | 1 | 9.70 |
| CHEMBL4164447 | — | — | 1 | 9.70 |
| CHEMBL4175085 | — | — | 1 | 9.70 |
| CHEMBL4171332 | — | — | 1 | 9.70 |
| CHEMBL4160734 | — | — | 1 | 9.70 |
| CHEMBL4174789 | — | — | 1 | 9.70 |
| CHEMBL4169918 | — | — | 1 | 9.70 |
| CHEMBL4162508 | — | — | 1 | 9.70 |
| CHEMBL4163562 | — | — | 1 | 9.52 |
| CHEMBL4167575 | — | — | 1 | 9.52 |
| CHEMBL4169627 | — | — | 1 | 9.52 |
| CHEMBL4169959 | — | — | 1 | 9.40 |
| CHEMBL4167152 | — | — | 1 | 9.40 |
| CHEMBL4165638 | — | — | 1 | 9.00 |
| CHEMBL4175025 | — | — | 1 | 8.59 |
| CHEMBL4159900 | — | — | 1 | 8.37 |
| CHEMBL4170549 | — | — | 1 | 8.00 |
| CHEMBL4173984 | — | — | 1 | 7.57 |
| CHEMBL4159656 | — | — | 1 | 7.23 |
| CHEMBL4165523 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164869 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4168008 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4159755 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4164133 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4171078 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4161695 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4163162 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4175179 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4161455 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4176563 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4164447 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4175085 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4171332 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4160734 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4174789 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4169918 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4162508 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4163562 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4167575 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4169627 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4169959 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4167152 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4165638 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4175025 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4159900 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4170549 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4173984 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4159656 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4165523 | — | IC50 | - | — | - |