Assay Detail
Functional
CHEMBL4151772
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Protection against cisplatin-induced cell death in neonatal mouse HEI-OC1 cells assessed as reduction in caspase-3/7 activity
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of Second-Generation CDK2 Inhibitors for the Prevention of Cisplatin-Induced Hearing Loss.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 53 | 6.07 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457177 | — | — | 1 | 7.89 |
| CHEMBL510578 | — | — | 1 | 7.36 |
| CHEMBL411491 | — | — | 1 | 6.90 |
| CHEMBL409450 | 6BIO | — | 1 | 6.72 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 6.46 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 6.42 |
| CHEMBL4160645 | — | — | 1 | 6.34 |
| CHEMBL518383 | — | — | 1 | 6.29 |
| CHEMBL1094304 | OLOMOUCINE II | — | 1 | 6.22 |
| CHEMBL488436 | AZD-5438 | 1.0 | 1 | 6.16 |
| CHEMBL258805 | SU-9516 | 1.0 | 1 | 5.80 |
| CHEMBL497477 | — | — | 1 | 5.58 |
| CHEMBL4162724 | — | — | 1 | 5.44 |
| CHEMBL4161715 | — | — | 1 | 5.30 |
| CHEMBL4172348 | — | — | 1 | 5.17 |
| CHEMBL457388 | — | — | 1 | 4.65 |
| CHEMBL4175760 | — | — | 1 | 4.51 |
| CHEMBL507167 | — | — | 1 | - |
| CHEMBL1187319 | — | — | 1 | - |
| CHEMBL463580 | — | — | 1 | - |
| CHEMBL448316 | — | — | 1 | - |
| CHEMBL497306 | — | — | 1 | - |
| CHEMBL456963 | — | — | 1 | - |
| CHEMBL4164227 | — | — | 1 | - |
| CHEMBL4165150 | — | — | 1 | - |
| CHEMBL463579 | — | — | 1 | - |
| CHEMBL457208 | — | — | 1 | - |
| CHEMBL4167022 | — | — | 1 | - |
| CHEMBL1233922 | — | — | 1 | - |
| CHEMBL4177286 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457177 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL510578 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL411491 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL409450 | 6BIO | EC50 | = | 192.0 | nM | 6.72 |
| CHEMBL296586 | KENPAULLONE | EC50 | = | 349.0 | nM | 6.46 |
| CHEMBL445813 | AT-7519 | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4160645 | — | EC50 | = | 459.0 | nM | 6.34 |
| CHEMBL518383 | — | EC50 | = | 507.0 | nM | 6.29 |
| CHEMBL1094304 | OLOMOUCINE II | EC50 | = | 595.0 | nM | 6.22 |
| CHEMBL488436 | AZD-5438 | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL258805 | SU-9516 | EC50 | = | 1594.0 | nM | 5.80 |
| CHEMBL497477 | — | EC50 | = | 2606.0 | nM | 5.58 |
| CHEMBL4162724 | — | EC50 | = | 3634.0 | nM | 5.44 |
| CHEMBL4161715 | — | EC50 | = | 5039.0 | nM | 5.30 |
| CHEMBL4172348 | — | EC50 | = | 6753.0 | nM | 5.17 |
| CHEMBL457388 | — | EC50 | = | 22463.0 | nM | 4.65 |
| CHEMBL4175760 | — | EC50 | = | 31149.0 | nM | 4.51 |
| CHEMBL4171046 | — | EC50 | - | — | - | |
| CHEMBL4160443 | — | EC50 | - | — | - | |
| CHEMBL4167673 | — | EC50 | - | — | - | |
| CHEMBL4175542 | — | EC50 | - | — | - | |
| CHEMBL4169165 | — | EC50 | - | — | - | |
| CHEMBL4177018 | — | EC50 | - | — | - | |
| CHEMBL4171467 | — | EC50 | - | — | - | |
| CHEMBL3465750 | — | EC50 | - | — | - | |
| CHEMBL4174904 | — | EC50 | - | — | - | |
| CHEMBL4162158 | — | EC50 | - | — | - | |
| CHEMBL4159787 | — | EC50 | - | — | - | |
| CHEMBL4170432 | — | EC50 | - | — | - | |
| CHEMBL3446136 | — | EC50 | - | — | - | |
| CHEMBL4173863 | — | EC50 | - | — | - | |
| CHEMBL4176367 | — | EC50 | - | — | - | |
| CHEMBL4168510 | — | EC50 | - | — | - | |
| CHEMBL463579 | — | EC50 | > | 32219.0 | nM | - |
| CHEMBL507167 | — | EC50 | > | 33457.0 | nM | - |
| CHEMBL1187319 | — | EC50 | > | 37918.0 | nM | - |
| CHEMBL463580 | — | EC50 | > | 33208.0 | nM | - |
| CHEMBL448316 | — | EC50 | > | 30855.0 | nM | - |
| CHEMBL497306 | — | EC50 | > | 37174.7 | nM | - |
| CHEMBL456963 | — | EC50 | > | 27260.0 | nM | - |
| CHEMBL4164227 | — | EC50 | - | — | - | |
| CHEMBL4165150 | — | EC50 | > | 49442.0 | nM | - |
| CHEMBL4165594 | — | EC50 | - | — | - | |
| CHEMBL457208 | — | EC50 | > | 32714.0 | nM | - |
| CHEMBL4167022 | — | EC50 | - | — | - | |
| CHEMBL1233922 | — | EC50 | - | — | - | |
| CHEMBL4177286 | — | EC50 | - | — | - | |
| CHEMBL4176886 | — | EC50 | - | — | - | |
| CHEMBL4169026 | — | EC50 | - | — | - | |
| CHEMBL329129 | — | EC50 | - | — | - |