Assay Detail
Binding
CHEMBL4152099
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HDAC6 incubated for 90 mins using fluorogenic substrate ZMAL (Z-Lys(Ac)-AMC) by fluorescence based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.89 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4162282 | — | — | 1 | 8.52 |
| CHEMBL4173361 | — | — | 1 | 7.96 |
| CHEMBL4170198 | — | — | 1 | 7.85 |
| CHEMBL4165724 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4162282 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4173361 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4170198 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4165724 | — | IC50 | = | 60.0 | nM | 7.22 |