Assay Detail
Functional
CHEMBL4152103
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Cytotoxicity in human RPMI7951 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-7951 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.62 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4175942 | — | — | 1 | 8.48 |
| CHEMBL4172535 | — | — | 1 | 8.25 |
| CHEMBL2163631 | SABIZABULIN | 3.0 | 1 | 8.14 |
| CHEMBL4163251 | — | — | 1 | 8.06 |
| CHEMBL4177000 | — | — | 1 | 7.54 |
| CHEMBL4165318 | — | — | 1 | 7.46 |
| CHEMBL4161885 | — | — | 1 | 7.32 |
| CHEMBL4173640 | — | — | 1 | 6.67 |
| CHEMBL4169149 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4175942 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4172535 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL2163631 | SABIZABULIN | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4163251 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4177000 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL4165318 | — | IC50 | = | 34.8 | nM | 7.46 |
| CHEMBL4161885 | — | IC50 | = | 47.7 | nM | 7.32 |
| CHEMBL4173640 | — | IC50 | = | 213.7 | nM | 6.67 |
| CHEMBL4169149 | — | IC50 | = | 235.6 | nM | 6.63 |