Assay Detail
Functional
CHEMBL4152105
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Cytotoxicity in human PC3-TxR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.53 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4175942 | — | — | 1 | 8.12 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4175942 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 113.9 | nM | 6.94 |