Assay Detail
Binding
CHEMBL4152535
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Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measured after 1 min by RP-HPLC method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.82 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 6.52 |
| CHEMBL445599 | — | — | 1 | 6.52 |
| CHEMBL225421 | ARZANOL | — | 1 | 6.40 |
| CHEMBL3770253 | — | — | 1 | 6.40 |
| CHEMBL2006643 | — | — | 1 | 6.37 |
| CHEMBL173395 | ATRANORIN | — | 1 | 5.94 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 5.75 |
| CHEMBL4163039 | — | — | 1 | 5.70 |
| CHEMBL29097 | — | — | 1 | 5.68 |
| CHEMBL4170957 | — | — | 1 | 5.55 |
| CHEMBL237111 | AKBA | -1.0 | 1 | 5.52 |
| CHEMBL218693 | CARNOSOL | — | 1 | 5.30 |
| CHEMBL484853 | CARNOSIC ACID | — | 1 | 5.30 |
| CHEMBL267225 | BOSWELLIC ACID | 2.0 | 1 | 5.30 |
| CHEMBL437964 | 11-KETO BOSWELLIC ACID | — | 1 | 5.00 |
| CHEMBL236906 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL445599 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL225421 | ARZANOL | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3770253 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2006643 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL173395 | ATRANORIN | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4163039 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL29097 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4170957 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL237111 | AKBA | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL218693 | CARNOSOL | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL484853 | CARNOSIC ACID | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL267225 | BOSWELLIC ACID | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL437964 | 11-KETO BOSWELLIC ACID | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL236906 | — | IC50 | >= | 30000.0 | nM | - |