Assay Detail
Functional
CHEMBL4152599
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Growth inhibition of human HepG2 cells after 24 hrs by MTT assay
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 66 | 4.89 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4175859 | — | — | 1 | 6.48 |
| CHEMBL4165235 | — | — | 1 | 6.21 |
| CHEMBL4159117 | — | — | 1 | 5.92 |
| CHEMBL4171413 | — | — | 1 | 5.89 |
| CHEMBL4159733 | — | — | 1 | 5.74 |
| CHEMBL4167023 | — | — | 1 | 5.58 |
| CHEMBL4160994 | — | — | 1 | 5.53 |
| CHEMBL4167578 | — | — | 1 | 5.50 |
| CHEMBL4070828 | — | — | 1 | 5.49 |
| CHEMBL4160352 | — | — | 1 | 5.39 |
| CHEMBL4169966 | — | — | 1 | 5.28 |
| CHEMBL4175456 | — | — | 1 | 5.28 |
| CHEMBL4174198 | — | — | 1 | 5.27 |
| CHEMBL4163494 | — | — | 1 | 5.22 |
| CHEMBL4173812 | — | — | 1 | 5.20 |
| CHEMBL4170956 | — | — | 1 | 5.18 |
| CHEMBL4170433 | — | — | 1 | 5.14 |
| CHEMBL4173864 | — | — | 1 | 5.09 |
| CHEMBL4159352 | — | — | 1 | 5.06 |
| CHEMBL4097936 | — | — | 1 | 5.04 |
| CHEMBL4169374 | — | — | 1 | 5.00 |
| CHEMBL4177146 | — | — | 1 | 5.00 |
| CHEMBL4173797 | — | — | 1 | 5.00 |
| CHEMBL4168657 | — | — | 1 | 4.99 |
| CHEMBL4171603 | — | — | 1 | 4.98 |
| CHEMBL4166960 | — | — | 1 | 4.94 |
| CHEMBL388525 | — | — | 1 | 4.93 |
| CHEMBL4170827 | — | — | 1 | 4.91 |
| CHEMBL4080686 | — | — | 1 | 4.90 |
| CHEMBL4169341 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4175859 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4165235 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4159117 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4171413 | — | IC50 | = | 1281.0 | nM | 5.89 |
| CHEMBL4159733 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4167023 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL4160994 | — | IC50 | = | 2953.0 | nM | 5.53 |
| CHEMBL4167578 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL4070828 | — | IC50 | = | 3212.0 | nM | 5.49 |
| CHEMBL4160352 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL4169966 | — | IC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL4175456 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL4174198 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL4163494 | — | IC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL4173812 | — | IC50 | = | 6353.0 | nM | 5.20 |
| CHEMBL4170956 | — | IC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL4170433 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL4173864 | — | IC50 | = | 8130.0 | nM | 5.09 |
| CHEMBL4159352 | — | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL4097936 | — | IC50 | = | 9220.0 | nM | 5.04 |
| CHEMBL4169374 | — | IC50 | = | 10090.0 | nM | 5.00 |
| CHEMBL4177146 | — | IC50 | = | 9910.0 | nM | 5.00 |
| CHEMBL4173797 | — | IC50 | = | 10090.0 | nM | 5.00 |
| CHEMBL4168657 | — | IC50 | = | 10230.0 | nM | 4.99 |
| CHEMBL4171603 | — | IC50 | = | 10560.0 | nM | 4.98 |
| CHEMBL4166960 | — | IC50 | = | 11390.0 | nM | 4.94 |
| CHEMBL388525 | — | IC50 | = | 11710.0 | nM | 4.93 |
| CHEMBL4170827 | — | IC50 | = | 12310.0 | nM | 4.91 |
| CHEMBL4080686 | — | IC50 | = | 12710.0 | nM | 4.90 |
| CHEMBL4169341 | — | IC50 | = | 12770.0 | nM | 4.89 |
| CHEMBL4170366 | — | IC50 | = | 13150.0 | nM | 4.88 |
| CHEMBL4173414 | — | IC50 | = | 13590.0 | nM | 4.87 |
| CHEMBL4160738 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4177216 | — | IC50 | = | 13960.0 | nM | 4.86 |
| CHEMBL4177243 | — | IC50 | = | 15250.0 | nM | 4.82 |
| CHEMBL4163081 | — | IC50 | = | 17390.0 | nM | 4.76 |
| CHEMBL4160206 | — | IC50 | = | 20520.0 | nM | 4.69 |
| CHEMBL4172008 | — | IC50 | = | 21540.0 | nM | 4.67 |
| CHEMBL4163102 | — | IC50 | = | 21160.0 | nM | 4.67 |
| CHEMBL4169306 | — | IC50 | = | 22290.0 | nM | 4.65 |
| CHEMBL4176568 | — | IC50 | = | 23650.0 | nM | 4.63 |
| CHEMBL4173202 | — | IC50 | = | 26350.0 | nM | 4.58 |
| CHEMBL4164134 | — | IC50 | = | 32520.0 | nM | 4.49 |
| CHEMBL4164228 | — | IC50 | = | 33040.0 | nM | 4.48 |
| CHEMBL4164992 | — | IC50 | = | 33270.0 | nM | 4.48 |
| CHEMBL4162729 | — | IC50 | = | 42060.0 | nM | 4.38 |
| CHEMBL4164527 | — | IC50 | = | 43060.0 | nM | 4.37 |
| CHEMBL4174091 | — | IC50 | = | 52080.0 | nM | 4.28 |
| CHEMBL2170567 | — | IC50 | = | 52550.0 | nM | 4.28 |
| CHEMBL4177162 | — | IC50 | = | 53590.0 | nM | 4.27 |