Assay Detail
Functional
CHEMBL4152600
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Growth inhibition of human MDA-MB-231 cells after 24 hrs by MTT assay
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 66 | 4.70 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165235 | — | — | 1 | 6.35 |
| CHEMBL4097936 | — | — | 1 | 6.34 |
| CHEMBL4175859 | — | — | 1 | 6.24 |
| CHEMBL4173414 | — | — | 1 | 5.52 |
| CHEMBL4169966 | — | — | 1 | 5.37 |
| CHEMBL4070828 | — | — | 1 | 5.28 |
| CHEMBL4168657 | — | — | 1 | 5.20 |
| CHEMBL4174198 | — | — | 1 | 5.11 |
| CHEMBL4080686 | — | — | 1 | 5.06 |
| CHEMBL4170433 | — | — | 1 | 5.03 |
| CHEMBL4164992 | — | — | 1 | 5.03 |
| CHEMBL4160738 | — | — | 1 | 5.01 |
| CHEMBL4163494 | — | — | 1 | 5.01 |
| CHEMBL4173864 | — | — | 1 | 4.99 |
| CHEMBL4171413 | — | — | 1 | 4.99 |
| CHEMBL4173202 | — | — | 1 | 4.98 |
| CHEMBL4167023 | — | — | 1 | 4.96 |
| CHEMBL4172008 | — | — | 1 | 4.95 |
| CHEMBL4173797 | — | — | 1 | 4.95 |
| CHEMBL4169374 | — | — | 1 | 4.95 |
| CHEMBL388525 | — | — | 1 | 4.93 |
| CHEMBL4159117 | — | — | 1 | 4.82 |
| CHEMBL4162729 | — | — | 1 | 4.79 |
| CHEMBL4166960 | — | — | 1 | 4.73 |
| CHEMBL4159733 | — | — | 1 | 4.70 |
| CHEMBL4174091 | — | — | 1 | 4.65 |
| CHEMBL4167578 | — | — | 1 | 4.63 |
| CHEMBL4163081 | — | — | 1 | 4.55 |
| CHEMBL4160994 | — | — | 1 | 4.51 |
| CHEMBL4164527 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165235 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4097936 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4175859 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4173414 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL4169966 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL4070828 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL4168657 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL4174198 | — | IC50 | = | 7790.0 | nM | 5.11 |
| CHEMBL4080686 | — | IC50 | = | 8620.0 | nM | 5.06 |
| CHEMBL4170433 | — | IC50 | = | 9270.0 | nM | 5.03 |
| CHEMBL4164992 | — | IC50 | = | 9290.0 | nM | 5.03 |
| CHEMBL4160738 | — | IC50 | = | 9680.0 | nM | 5.01 |
| CHEMBL4163494 | — | IC50 | = | 9740.0 | nM | 5.01 |
| CHEMBL4171413 | — | IC50 | = | 10320.0 | nM | 4.99 |
| CHEMBL4173864 | — | IC50 | = | 10250.0 | nM | 4.99 |
| CHEMBL4173202 | — | IC50 | = | 10550.0 | nM | 4.98 |
| CHEMBL4167023 | — | IC50 | = | 11050.0 | nM | 4.96 |
| CHEMBL4172008 | — | IC50 | = | 11220.0 | nM | 4.95 |
| CHEMBL4173797 | — | IC50 | = | 11220.0 | nM | 4.95 |
| CHEMBL4169374 | — | IC50 | = | 11220.0 | nM | 4.95 |
| CHEMBL388525 | — | IC50 | = | 11620.0 | nM | 4.93 |
| CHEMBL4159117 | — | IC50 | = | 15010.0 | nM | 4.82 |
| CHEMBL4162729 | — | IC50 | = | 16250.0 | nM | 4.79 |
| CHEMBL4166960 | — | IC50 | = | 18490.0 | nM | 4.73 |
| CHEMBL4159733 | — | IC50 | = | 19760.0 | nM | 4.70 |
| CHEMBL4174091 | — | IC50 | = | 22280.0 | nM | 4.65 |
| CHEMBL4167578 | — | IC50 | = | 23460.0 | nM | 4.63 |
| CHEMBL4163081 | — | IC50 | = | 27840.0 | nM | 4.55 |
| CHEMBL4160994 | — | IC50 | = | 30680.0 | nM | 4.51 |
| CHEMBL4164527 | — | IC50 | = | 33270.0 | nM | 4.48 |
| CHEMBL4174486 | — | IC50 | = | 35560.0 | nM | 4.45 |
| CHEMBL4176568 | — | IC50 | = | 41080.0 | nM | 4.39 |
| CHEMBL4160352 | — | IC50 | = | 40670.0 | nM | 4.39 |
| CHEMBL4165297 | — | IC50 | = | 41370.0 | nM | 4.38 |
| CHEMBL4177216 | — | IC50 | = | 43560.0 | nM | 4.36 |
| CHEMBL4175456 | — | IC50 | = | 43540.0 | nM | 4.36 |
| CHEMBL4177146 | — | IC50 | = | 44650.0 | nM | 4.35 |
| CHEMBL4173812 | — | IC50 | = | 45580.0 | nM | 4.34 |
| CHEMBL71263 | VADIMEZAN | IC50 | = | 48420.0 | nM | 4.32 |
| CHEMBL4168706 | — | IC50 | = | 51460.0 | nM | 4.29 |
| CHEMBL4170956 | — | IC50 | = | 56600.0 | nM | 4.25 |
| CHEMBL4159352 | — | IC50 | = | 55880.0 | nM | 4.25 |
| CHEMBL4171603 | — | IC50 | = | 62870.0 | nM | 4.20 |
| CHEMBL4164134 | — | IC50 | = | 65980.0 | nM | 4.18 |
| CHEMBL4169778 | — | IC50 | = | 66690.0 | nM | 4.18 |
| CHEMBL4170366 | — | IC50 | = | 67580.0 | nM | 4.17 |
| CHEMBL4177243 | — | IC50 | = | 74340.0 | nM | 4.13 |
| CHEMBL4169341 | — | IC50 | = | 78360.0 | nM | 4.11 |
| CHEMBL4161852 | — | IC50 | = | 82720.0 | nM | 4.08 |
| CHEMBL4170827 | — | IC50 | = | 83880.0 | nM | 4.08 |