Assay Detail
Functional
CHEMBL4152601
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Growth inhibition of human MCF7 cells after 24 hrs by MTT assay
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 66 | 4.43 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4070828 | — | — | 1 | 5.92 |
| CHEMBL4097936 | — | — | 1 | 5.47 |
| CHEMBL4080686 | — | — | 1 | 5.38 |
| CHEMBL388525 | — | — | 1 | 4.95 |
| CHEMBL4163494 | — | — | 1 | 4.88 |
| CHEMBL4174198 | — | — | 1 | 4.60 |
| CHEMBL4173864 | — | — | 1 | 4.51 |
| CHEMBL4165235 | — | — | 1 | 4.51 |
| CHEMBL4175859 | — | — | 1 | 4.48 |
| CHEMBL4171413 | — | — | 1 | 4.45 |
| CHEMBL4170433 | — | — | 1 | 4.45 |
| CHEMBL4160994 | — | — | 1 | 4.40 |
| CHEMBL4173414 | — | — | 1 | 4.39 |
| CHEMBL4173797 | — | — | 1 | 4.37 |
| CHEMBL4159352 | — | — | 1 | 4.37 |
| CHEMBL4169374 | — | — | 1 | 4.37 |
| CHEMBL4159117 | — | — | 1 | 4.36 |
| CHEMBL4171603 | — | — | 1 | 4.32 |
| CHEMBL4169966 | — | — | 1 | 4.27 |
| CHEMBL4163081 | — | — | 1 | 4.27 |
| CHEMBL4166960 | — | — | 1 | 4.27 |
| CHEMBL4164992 | — | — | 1 | 4.27 |
| CHEMBL71263 | VADIMEZAN | 3.0 | 1 | 4.26 |
| CHEMBL4168657 | — | — | 1 | 4.20 |
| CHEMBL4169341 | — | — | 1 | 4.20 |
| CHEMBL4162729 | — | — | 1 | 4.15 |
| CHEMBL4164527 | — | — | 1 | 4.13 |
| CHEMBL4167023 | — | — | 1 | 4.13 |
| CHEMBL4174091 | — | — | 1 | 4.08 |
| CHEMBL2170567 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4070828 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4097936 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL4080686 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL388525 | — | IC50 | = | 11230.0 | nM | 4.95 |
| CHEMBL4163494 | — | IC50 | = | 13320.0 | nM | 4.88 |
| CHEMBL4174198 | — | IC50 | = | 25140.0 | nM | 4.60 |
| CHEMBL4173864 | — | IC50 | = | 30830.0 | nM | 4.51 |
| CHEMBL4165235 | — | IC50 | = | 31030.0 | nM | 4.51 |
| CHEMBL4175859 | — | IC50 | = | 33070.0 | nM | 4.48 |
| CHEMBL4171413 | — | IC50 | = | 35130.0 | nM | 4.45 |
| CHEMBL4170433 | — | IC50 | = | 35850.0 | nM | 4.45 |
| CHEMBL4160994 | — | IC50 | = | 39450.0 | nM | 4.40 |
| CHEMBL4173414 | — | IC50 | = | 41130.0 | nM | 4.39 |
| CHEMBL4159352 | — | IC50 | = | 42690.0 | nM | 4.37 |
| CHEMBL4173797 | — | IC50 | = | 42920.0 | nM | 4.37 |
| CHEMBL4169374 | — | IC50 | = | 42920.0 | nM | 4.37 |
| CHEMBL4159117 | — | IC50 | = | 43460.0 | nM | 4.36 |
| CHEMBL4171603 | — | IC50 | = | 47680.0 | nM | 4.32 |
| CHEMBL4169966 | — | IC50 | = | 53520.0 | nM | 4.27 |
| CHEMBL4163081 | — | IC50 | = | 53400.0 | nM | 4.27 |
| CHEMBL4166960 | — | IC50 | = | 53730.0 | nM | 4.27 |
| CHEMBL4164992 | — | IC50 | = | 53420.0 | nM | 4.27 |
| CHEMBL71263 | VADIMEZAN | IC50 | = | 54400.0 | nM | 4.26 |
| CHEMBL4168657 | — | IC50 | = | 62950.0 | nM | 4.20 |
| CHEMBL4169341 | — | IC50 | = | 62780.0 | nM | 4.20 |
| CHEMBL4162729 | — | IC50 | = | 71250.0 | nM | 4.15 |
| CHEMBL4167023 | — | IC50 | = | 73240.0 | nM | 4.13 |
| CHEMBL4164527 | — | IC50 | = | 74320.0 | nM | 4.13 |
| CHEMBL4174091 | — | IC50 | = | 83250.0 | nM | 4.08 |
| CHEMBL2170567 | — | IC50 | = | 89730.0 | nM | 4.05 |
| CHEMBL4177146 | — | IC50 | = | 91210.0 | nM | 4.04 |
| CHEMBL4167578 | — | IC50 | = | 93140.0 | nM | 4.03 |
| CHEMBL4174486 | — | IC50 | = | 98190.0 | nM | 4.01 |
| CHEMBL4159733 | — | IC50 | = | 98160.0 | nM | 4.01 |
| CHEMBL3357571 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4174664 | — | IC50 | = | 102300.0 | nM | - |
| CHEMBL4169306 | — | IC50 | = | 143400.0 | nM | - |
| CHEMBL4164228 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4166763 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL361025 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4161852 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4169778 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4165297 | — | IC50 | = | 111600.0 | nM | - |
| CHEMBL4173202 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4177243 | — | IC50 | = | 112300.0 | nM | - |
| CHEMBL4163822 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4168706 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4176568 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4172056 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1817841 | ABRUCOMSTAT | IC50 | > | 200000.0 | nM | - |