Assay Detail
Binding
CHEMBL4152830
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Binding affinity to wild-type human partial length ALK (I1088 to E1409 residues) expressed in mammalian expression system by KINOMEscan assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.68 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 8.89 |
| CHEMBL4161454 | — | — | 1 | 7.72 |
| CHEMBL4165519 | — | — | 1 | 7.43 |
| CHEMBL4159122 | — | — | 1 | 7.27 |
| CHEMBL4169769 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2403108 | CERITINIB | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL4161454 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL4165519 | — | Kd | = | 37.0 | nM | 7.43 |
| CHEMBL4159122 | — | Kd | = | 54.0 | nM | 7.27 |
| CHEMBL4169769 | — | Kd | = | 78.0 | nM | 7.11 |