Assay Detail
Functional
CHEMBL4152982
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Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bel-7402 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antiproliferative hydrogen sulfide releasing evodiamine derivatives and their apoptosis inducing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.63 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81925 | — | — | 1 | 5.92 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.72 |
| CHEMBL4164437 | — | — | 1 | 4.69 |
| CHEMBL4168298 | — | — | 1 | 4.66 |
| CHEMBL4176141 | — | — | 1 | 4.59 |
| CHEMBL4161448 | — | — | 1 | 4.57 |
| CHEMBL4170103 | — | — | 1 | 4.51 |
| CHEMBL4173556 | — | — | 1 | 4.46 |
| CHEMBL4165625 | — | — | 1 | 4.38 |
| CHEMBL4161791 | — | — | 1 | 4.35 |
| CHEMBL4169372 | — | — | 1 | 4.34 |
| CHEMBL4169056 | — | — | 1 | 4.31 |
| CHEMBL4167868 | — | — | 1 | - |
| CHEMBL4159949 | — | — | 1 | - |
| CHEMBL4171636 | — | — | 1 | - |
| CHEMBL4161032 | — | — | 1 | - |
| CHEMBL134342 | THIOCTIC ACID | — | 1 | - |
| CHEMBL4162194 | — | — | 1 | - |
| CHEMBL4172434 | — | — | 1 | - |
| CHEMBL402341 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81925 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 18970.0 | nM | 4.72 |
| CHEMBL4164437 | — | IC50 | = | 20530.0 | nM | 4.69 |
| CHEMBL4168298 | — | IC50 | = | 22060.0 | nM | 4.66 |
| CHEMBL4176141 | — | IC50 | = | 25830.0 | nM | 4.59 |
| CHEMBL4161448 | — | IC50 | = | 26840.0 | nM | 4.57 |
| CHEMBL4170103 | — | IC50 | = | 30540.0 | nM | 4.51 |
| CHEMBL4173556 | — | IC50 | = | 34250.0 | nM | 4.46 |
| CHEMBL4165625 | — | IC50 | = | 41360.0 | nM | 4.38 |
| CHEMBL4161791 | — | IC50 | = | 45030.0 | nM | 4.35 |
| CHEMBL4169372 | — | IC50 | = | 45240.0 | nM | 4.34 |
| CHEMBL4169056 | — | IC50 | = | 48940.0 | nM | 4.31 |
| CHEMBL4167868 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4159949 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4171636 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4161032 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL134342 | THIOCTIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL4162194 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4172434 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL402341 | — | IC50 | > | 50000.0 | nM | - |