Assay Detail
Functional
CHEMBL4153227
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Antiproliferative activity against human TS15-88 cells after 24 to 72 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.62 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4171354 | — | — | 1 | 5.05 |
| CHEMBL4175330 | — | — | 1 | 4.59 |
| CHEMBL4159289 | — | — | 1 | 4.45 |
| CHEMBL4175875 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4171354 | — | IC50 | = | 8920.0 | nM | 5.05 |
| CHEMBL4175330 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL4159289 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL4175875 | — | IC50 | = | 40000.0 | nM | 4.40 |