Assay Detail
Binding
CHEMBL4153311
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant COX2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by ADPH probe-based fluorescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel Methylsulfonyl phenyl derivatives as potent human Cyclooxygenase-2 inhibitors with effective anticonvulsant action: Design, synthesis, in-silico, in-vitro and in-vivo evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.32 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416146 | ETORICOXIB | 4.0 | 1 | 5.96 |
| CHEMBL4170210 | — | — | 1 | 5.67 |
| CHEMBL4162939 | — | — | 1 | 5.50 |
| CHEMBL4169819 | — | — | 1 | 5.27 |
| CHEMBL4177013 | — | — | 1 | 5.19 |
| CHEMBL4173650 | — | — | 1 | 5.15 |
| CHEMBL4166395 | — | — | 1 | 4.90 |
| CHEMBL4159582 | — | — | 1 | 4.89 |
| CHEMBL4161896 | — | — | 1 | - |
| CHEMBL4173245 | — | — | 1 | - |
| CHEMBL4165330 | — | — | 1 | - |
| CHEMBL4163920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416146 | ETORICOXIB | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4170210 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4162939 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL4169819 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL4177013 | — | IC50 | = | 6420.0 | nM | 5.19 |
| CHEMBL4173650 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL4166395 | — | IC50 | = | 12490.0 | nM | 4.90 |
| CHEMBL4159582 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4161896 | — | IC50 | - | — | - | |
| CHEMBL4173245 | — | IC50 | - | — | - | |
| CHEMBL4165330 | — | IC50 | - | — | - | |
| CHEMBL4163920 | — | IC50 | - | — | - |