Assay Detail
Functional
CHEMBL4153476
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Cytotoxicity against human PANC1 cells after 72 hrs under normoxic condition by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PANC-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses and anti-pancreatic cancer activities of rakicidin A analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.30 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4166855 | — | — | 1 | 6.96 |
| CHEMBL4164532 | — | — | 1 | 6.92 |
| CHEMBL4171928 | — | — | 1 | 6.89 |
| CHEMBL4167966 | — | — | 1 | 6.82 |
| CHEMBL4167438 | — | — | 1 | 6.80 |
| CHEMBL4161330 | — | — | 1 | 6.77 |
| CHEMBL4171301 | — | — | 1 | 6.75 |
| CHEMBL3774991 | — | — | 1 | 6.66 |
| CHEMBL3775684 | — | — | 1 | 6.57 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.40 |
| CHEMBL4162089 | — | — | 1 | 6.39 |
| CHEMBL4168578 | — | — | 1 | 6.37 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.32 |
| CHEMBL4163572 | — | — | 1 | 6.19 |
| CHEMBL4174757 | — | — | 1 | 6.18 |
| CHEMBL4171719 | — | — | 1 | 6.00 |
| CHEMBL4161116 | — | — | 1 | 5.96 |
| CHEMBL4176440 | — | — | 1 | 5.96 |
| CHEMBL4163403 | — | — | 1 | 5.75 |
| CHEMBL4175163 | — | — | 1 | 5.61 |
| CHEMBL4164225 | — | — | 1 | 5.60 |
| CHEMBL4160040 | — | — | 1 | 4.68 |
| CHEMBL4172765 | — | — | 1 | - |
| CHEMBL4164752 | — | — | 1 | - |
| CHEMBL4175375 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4166855 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4164532 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4171928 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4167966 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4167438 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4161330 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4171301 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3774991 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3775684 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4162089 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4168578 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4163572 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4174757 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4171719 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4161116 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4176440 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4163403 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4175163 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4164225 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4160040 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4172765 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4164752 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4175375 | — | IC50 | > | 10000.0 | nM | - |