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Assay Detail

CHEMBL4153478

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human Aspc-1 cells after 72 hrs under normoxic condition by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type ASPC1
Confidence 1 — Organism
Curated By Intermediate

Target

ASPC1 (CHEMBL612588)
Type CELL-LINE
Organism Homo sapiens

Publication

Syntheses and anti-pancreatic cancer activities of rakicidin A analogues.
Chen J, Li J, Wu L, Geng Y, Yu J, Chong C, Wang M, Gao Y, Bai C, Ding Y, Chen Y, Zhang Q.
Eur J Med Chem (2018) 151 : 601 -627
PubMed 29656202 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.12 6.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4167966 1 6.58
CHEMBL4171928 1 6.57
CHEMBL4171301 1 6.55
CHEMBL4166855 1 6.44
CHEMBL4167438 1 6.32
CHEMBL4161330 1 6.30
CHEMBL3775684 1 6.27
CHEMBL3774991 1 6.17
CHEMBL4164532 1 6.01
CHEMBL4162089 1 5.92
CHEMBL4168578 1 5.85
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE 4.0 1 5.80
CHEMBL4174757 1 5.50
CHEMBL4175163 1 5.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4167966 IC50 = 260.0 nM 6.58
CHEMBL4171928 IC50 = 270.0 nM 6.57
CHEMBL4171301 IC50 = 280.0 nM 6.55
CHEMBL4166855 IC50 = 360.0 nM 6.44
CHEMBL4167438 IC50 = 480.0 nM 6.32
CHEMBL4161330 IC50 = 500.0 nM 6.30
CHEMBL3775684 IC50 = 540.0 nM 6.27
CHEMBL3774991 IC50 = 680.0 nM 6.17
CHEMBL4164532 IC50 = 980.0 nM 6.01
CHEMBL4162089 IC50 = 1200.0 nM 5.92
CHEMBL4168578 IC50 = 1400.0 nM 5.85
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE IC50 = 1600.0 nM 5.80
CHEMBL4174757 IC50 = 3200.0 nM 5.50
CHEMBL4175163 IC50 = 4170.0 nM 5.38