Assay Detail
Binding
CHEMBL4153707
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Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK293 cell membranes after 1 hr by microbeta TopCount analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural insights into serotonin receptor ligands polypharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.49 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4162688 | — | — | 1 | 5.85 |
| CHEMBL4177293 | — | — | 1 | 5.75 |
| CHEMBL4174981 | — | — | 1 | 5.72 |
| CHEMBL4174845 | — | — | 1 | 5.62 |
| CHEMBL4164143 | — | — | 1 | 5.60 |
| CHEMBL4164250 | — | — | 1 | 5.57 |
| CHEMBL4175296 | — | — | 1 | 5.47 |
| CHEMBL1613157 | — | — | 1 | 5.43 |
| CHEMBL4166667 | — | — | 1 | 5.29 |
| CHEMBL4170813 | — | — | 1 | 5.25 |
| CHEMBL4160177 | — | — | 1 | 5.24 |
| CHEMBL4166092 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4162688 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL4177293 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL4174981 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL4174845 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL4164143 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL4164250 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL4175296 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL1613157 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL4166667 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL4170813 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL4160177 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL4166092 | — | Ki | = | 9000.0 | nM | 5.05 |