Assay Detail
Binding
CHEMBL4154033
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to p53 Y220C mutant (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 4.84 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170894 | — | — | 1 | 5.00 |
| CHEMBL4165245 | — | — | 1 | 4.68 |
| CHEMBL1235116 | — | — | 1 | - |
| CHEMBL4173155 | — | — | 1 | - |
| CHEMBL1232243 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170894 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL4165245 | — | Kd | = | 21000.0 | nM | 4.68 |
| CHEMBL1235116 | — | Kd | = | 140000.0 | nM | - |
| CHEMBL4173155 | — | Kd | - | — | - | |
| CHEMBL1232243 | — | Kd | = | 820000.0 | nM | - |