Assay Detail
Functional
CHEMBL4154044
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Antiproliferative activity against human BxPC3 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BXPC-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.58 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170894 | — | — | 1 | 4.96 |
| CHEMBL4166006 | — | — | 1 | 4.75 |
| CHEMBL1235116 | — | — | 1 | 4.37 |
| CHEMBL4163657 | — | — | 1 | 4.24 |
| CHEMBL4168439 | — | — | 1 | - |
| CHEMBL4162051 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170894 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4166006 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1235116 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4163657 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4168439 | — | IC50 | - | — | - | |
| CHEMBL4162051 | — | IC50 | - | — | - |