Assay Detail
Functional
CHEMBL4154679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against Plasmodium falciparum D6 after 72 hrs by MSF assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationship of new antimalarial 1-aryl-3-susbtituted propanol derivatives: Synthesis, preliminary toxicity profiling, parasite life cycle stage studies, target exploration, and targeted delivery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.72 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.00 |
| CHEMBL4161303 | — | — | 1 | 7.10 |
| CHEMBL4176037 | — | — | 1 | 7.00 |
| CHEMBL4160247 | — | — | 1 | 7.00 |
| CHEMBL4166728 | — | — | 1 | 6.96 |
| CHEMBL4167122 | — | — | 1 | 6.92 |
| CHEMBL4159210 | — | — | 1 | 6.92 |
| CHEMBL4172859 | — | — | 1 | 6.82 |
| CHEMBL4177385 | — | — | 1 | 6.55 |
| CHEMBL4176231 | — | — | 1 | 5.43 |
| CHEMBL4162190 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4161303 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4176037 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4160247 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4166728 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4167122 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4159210 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4172859 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4177385 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4176231 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL4162190 | — | IC50 | = | 6320.0 | nM | 5.20 |