Assay Detail
Functional
CHEMBL4154741
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Antiplasmodial activity against GFP-fused Plasmodium berghei sporozoites infected in human HepG2A16 cells treated simultaneously with infection by fluorescence microscopic analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationship of new antimalarial 1-aryl-3-susbtituted propanol derivatives: Synthesis, preliminary toxicity profiling, parasite life cycle stage studies, target exploration, and targeted delivery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.24 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161303 | — | — | 1 | 5.57 |
| CHEMBL4167122 | — | — | 1 | 5.47 |
| CHEMBL506 | PRIMAQUINE | 4.0 | 1 | 5.44 |
| CHEMBL4176037 | — | — | 1 | 5.27 |
| CHEMBL4166728 | — | — | 1 | 4.92 |
| CHEMBL4164515 | — | — | 1 | 4.74 |
| CHEMBL4162044 | — | — | 1 | - |
| CHEMBL4166967 | — | — | 1 | - |
| CHEMBL4160247 | — | — | 1 | - |
| CHEMBL4161433 | — | — | 1 | - |
| CHEMBL4177385 | — | — | 1 | - |
| CHEMBL4172859 | — | — | 1 | - |
| CHEMBL4162190 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161303 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4167122 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL506 | PRIMAQUINE | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL4176037 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL4166728 | — | IC50 | = | 12080.0 | nM | 4.92 |
| CHEMBL4164515 | — | IC50 | = | 18240.0 | nM | 4.74 |
| CHEMBL4162044 | — | IC50 | - | — | - | |
| CHEMBL4166967 | — | IC50 | - | — | - | |
| CHEMBL4160247 | — | IC50 | - | — | - | |
| CHEMBL4161433 | — | IC50 | - | — | - | |
| CHEMBL4177385 | — | IC50 | - | — | - | |
| CHEMBL4172859 | — | IC50 | - | — | - | |
| CHEMBL4162190 | — | IC50 | - | — | - |