Assay Detail
Functional
CHEMBL4154742
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against Plasmodium falciparum FCR-3 sporozoites infected in human primary hepatocytes treated simultaneously with infection by DAPI staining based HCS analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationship of new antimalarial 1-aryl-3-susbtituted propanol derivatives: Synthesis, preliminary toxicity profiling, parasite life cycle stage studies, target exploration, and targeted delivery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.97 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506 | PRIMAQUINE | 4.0 | 1 | 6.40 |
| CHEMBL4164515 | — | — | 1 | 5.77 |
| CHEMBL4166728 | — | — | 1 | 5.75 |
| CHEMBL4162044 | — | — | 1 | - |
| CHEMBL4166967 | — | — | 1 | - |
| CHEMBL4160247 | — | — | 1 | - |
| CHEMBL4176037 | — | — | 1 | - |
| CHEMBL4161433 | — | — | 1 | - |
| CHEMBL4177385 | — | — | 1 | - |
| CHEMBL4172859 | — | — | 1 | - |
| CHEMBL4162190 | — | — | 1 | - |
| CHEMBL4167122 | — | — | 1 | - |
| CHEMBL4161303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506 | PRIMAQUINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4164515 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4166728 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4162044 | — | IC50 | - | — | - | |
| CHEMBL4166967 | — | IC50 | - | — | - | |
| CHEMBL4160247 | — | IC50 | - | — | - | |
| CHEMBL4176037 | — | IC50 | - | — | - | |
| CHEMBL4161433 | — | IC50 | - | — | - | |
| CHEMBL4177385 | — | IC50 | - | — | - | |
| CHEMBL4172859 | — | IC50 | - | — | - | |
| CHEMBL4162190 | — | IC50 | - | — | - | |
| CHEMBL4167122 | — | IC50 | - | — | - | |
| CHEMBL4161303 | — | IC50 | - | — | - |