Assay Detail
Binding
CHEMBL4154753
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Binding affinity to Plasmodium falciparum GRP94 nucleotide binding domain by SPR analysis
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship of new antimalarial 1-aryl-3-susbtituted propanol derivatives: Synthesis, preliminary toxicity profiling, parasite life cycle stage studies, target exploration, and targeted delivery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 9 | - | - |
| Kd | 2 | 7.77 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL585793 | — | — | 1 | 7.77 |
| CHEMBL4164515 | — | — | 1 | - |
| CHEMBL4160247 | — | — | 1 | - |
| CHEMBL4176037 | — | — | 1 | - |
| CHEMBL4177385 | — | — | 1 | - |
| CHEMBL4162190 | — | — | 1 | - |
| CHEMBL4159210 | — | — | 1 | - |
| CHEMBL4167122 | — | — | 1 | - |
| CHEMBL4161303 | — | — | 1 | - |
| CHEMBL4166728 | — | — | 1 | - |
| CHEMBL598685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL585793 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL4164515 | — | Activity | - | — | - | |
| CHEMBL4160247 | — | Activity | - | — | - | |
| CHEMBL4176037 | — | Activity | - | — | - | |
| CHEMBL4177385 | — | Activity | - | — | - | |
| CHEMBL4162190 | — | Activity | - | — | - | |
| CHEMBL4159210 | — | Activity | - | — | - | |
| CHEMBL4167122 | — | Activity | - | — | - | |
| CHEMBL4161303 | — | Activity | - | — | - | |
| CHEMBL4166728 | — | Activity | - | — | - | |
| CHEMBL598685 | — | Kd | = | 4480000.0 | nM | - |