Assay Detail
Binding
CHEMBL4155089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human Pim1 expressed in bacterial expression system using histone H1 as substrate after 30 mins by ADP-Glo reagent based luminescence assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.48 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.51 |
| CHEMBL4177432 | — | — | 1 | 7.13 |
| CHEMBL4163110 | — | — | 1 | 6.54 |
| CHEMBL4166554 | — | — | 1 | 6.12 |
| CHEMBL4170635 | — | — | 1 | 6.00 |
| CHEMBL4174068 | — | — | 1 | 5.55 |
| CHEMBL4166150 | — | — | 1 | - |
| CHEMBL4169579 | — | — | 1 | - |
| CHEMBL4177174 | — | — | 1 | - |
| CHEMBL4170051 | — | — | 1 | - |
| CHEMBL4162053 | — | — | 1 | - |
| CHEMBL4159749 | — | — | 1 | - |
| CHEMBL4170384 | — | — | 1 | - |
| CHEMBL4168687 | — | — | 1 | - |
| CHEMBL4173649 | — | — | 1 | - |
| CHEMBL4168098 | — | — | 1 | - |
| CHEMBL4175950 | — | — | 1 | - |
| CHEMBL4162709 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4177432 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4163110 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4166554 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4170635 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4174068 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4166150 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4169579 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4177174 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4170051 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4162053 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4159749 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4170384 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4168687 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4173649 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4168098 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4175950 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4162709 | — | IC50 | > | 10000.0 | nM | - |