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Assay Detail

CHEMBL4155229

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 9 (CHEMBL3594)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.
Angeli A, di Cesare Mannelli L, Lucarini E, Peat TS, Ghelardini C, Supuran CT.
Eur J Med Chem (2018) 154 : 210 -219
PubMed 29803994 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.70 8.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4161665 1 8.57
CHEMBL4166037 1 8.40
CHEMBL20 ACETAZOLAMIDE 4.0 1 7.59
CHEMBL4170523 1 7.33
CHEMBL4167276 1 6.54
CHEMBL4160022 1 6.47
CHEMBL4175141 1 6.35
CHEMBL4162595 1 6.26
CHEMBL4174088 1 6.16
CHEMBL4163381 1 6.15
CHEMBL4165761 1 6.07
CHEMBL4173679 1 6.00
CHEMBL4177456 1 5.97
CHEMBL4166837 1 5.94

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4161665 Ki = 2.7 nM 8.57
CHEMBL4166037 Ki = 4.0 nM 8.40
CHEMBL20 ACETAZOLAMIDE Ki = 25.8 nM 7.59
CHEMBL4170523 Ki = 46.4 nM 7.33
CHEMBL4167276 Ki = 286.3 nM 6.54
CHEMBL4160022 Ki = 337.4 nM 6.47
CHEMBL4175141 Ki = 450.1 nM 6.35
CHEMBL4162595 Ki = 548.6 nM 6.26
CHEMBL4174088 Ki = 697.4 nM 6.16
CHEMBL4163381 Ki = 709.8 nM 6.15
CHEMBL4165761 Ki = 845.0 nM 6.07
CHEMBL4173679 Ki = 1006.0 nM 6.00
CHEMBL4177456 Ki = 1071.0 nM 5.97
CHEMBL4166837 Ki = 1137.0 nM 5.94