Assay Detail
Functional
CHEMBL4155299
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Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) infected in MDCK cells expressing wild type neuraminidase assessed as protection against virus-induced cytopathic effect after 48 hrs by CellTiter96 aqueous non-radioactive cell proliferation assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.07 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4175602 | — | — | 1 | 9.10 |
| CHEMBL4172062 | — | — | 1 | 9.00 |
| CHEMBL4160792 | — | — | 1 | 8.70 |
| CHEMBL2206459 | — | — | 1 | 8.42 |
| CHEMBL81717 | — | — | 1 | 8.15 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.80 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.57 |
| CHEMBL4161862 | — | — | 1 | 7.05 |
| CHEMBL4164188 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4175602 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4172062 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4160792 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2206459 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL81717 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4161862 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4164188 | — | EC50 | = | 140.0 | nM | 6.85 |