Assay Detail
Functional
CHEMBL4155300
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) infected in MDCK cells expressing neuraminidase H275Y mutant assessed as protection against virus-induced cytopathic effect after 48 hrs by CellTiter96 aqueous non-radioactive cell proliferation assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.62 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 6.82 |
| CHEMBL4161862 | — | — | 1 | 6.32 |
| CHEMBL4164188 | — | — | 1 | 6.05 |
| CHEMBL81717 | — | — | 1 | 5.68 |
| CHEMBL4172062 | — | — | 1 | 5.18 |
| CHEMBL4160792 | — | — | 1 | 4.72 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4161862 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4164188 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL81717 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4172062 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4160792 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 26000.0 | nM | 4.58 |