Assay Detail
Functional
CHEMBL4155616
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SMMC7721 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SMMC-7721 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activities of dithiocarbamates containing 2(5H)-furanone-piperazine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.25 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.52 |
| CHEMBL4173473 | — | — | 1 | 8.40 |
| CHEMBL4170859 | — | — | 1 | 8.22 |
| CHEMBL4165545 | — | — | 1 | 8.22 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4173473 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4170859 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4165545 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL803 | CYTARABINE | IC50 | = | 13.0 | nM | 7.89 |