Assay Detail
Functional
CHEMBL4155655
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Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of podophyllotoxin derivatives as selective antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.52 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4174065 | — | — | 1 | 8.80 |
| CHEMBL4173096 | — | — | 1 | 8.55 |
| CHEMBL4165193 | — | — | 1 | 8.42 |
| CHEMBL4161759 | — | — | 1 | 8.17 |
| CHEMBL4176266 | — | — | 1 | 8.09 |
| CHEMBL4162216 | — | — | 1 | 8.03 |
| CHEMBL4166147 | — | — | 1 | 8.02 |
| CHEMBL4161374 | — | — | 1 | 7.89 |
| CHEMBL4169690 | — | — | 1 | 7.87 |
| CHEMBL4173527 | — | — | 1 | 7.83 |
| CHEMBL4165661 | — | — | 1 | 7.80 |
| CHEMBL4175511 | — | — | 1 | 7.76 |
| CHEMBL4162821 | — | — | 1 | 7.72 |
| CHEMBL4172889 | — | — | 1 | 7.70 |
| CHEMBL4167643 | — | — | 1 | 7.52 |
| CHEMBL4161162 | — | — | 1 | 7.21 |
| CHEMBL4164579 | — | — | 1 | 7.11 |
| CHEMBL4169082 | — | — | 1 | 7.10 |
| CHEMBL4172466 | — | — | 1 | 6.92 |
| CHEMBL4176475 | — | — | 1 | 6.89 |
| CHEMBL4168614 | — | — | 1 | 6.83 |
| CHEMBL4171971 | — | — | 1 | 6.65 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.64 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4174065 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4173096 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4165193 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4161759 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4176266 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4162216 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL4166147 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL4161374 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL4169690 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL4173527 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL4165661 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL4175511 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL4162821 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL4172889 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL4167643 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL4161162 | — | IC50 | = | 62.4 | nM | 7.21 |
| CHEMBL4164579 | — | IC50 | = | 76.9 | nM | 7.11 |
| CHEMBL4169082 | — | IC50 | = | 80.1 | nM | 7.10 |
| CHEMBL4172466 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4176475 | — | IC50 | = | 129.9 | nM | 6.89 |
| CHEMBL4168614 | — | IC50 | = | 147.9 | nM | 6.83 |
| CHEMBL4171971 | — | IC50 | = | 222.7 | nM | 6.65 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 228.2 | nM | 6.64 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 9469.5 | nM | 5.02 |