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Assay Detail

CHEMBL4155863

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-CCL2 from HCMV US28 expressed in HEK293 cells after 3 hrs by gamma counting method
15
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human betaherpesvirus 5
Cell Type HEK293
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Ligand-selective small molecule modulators of the constitutively active vGPCR US28.
Amărandi RM, Lückmann M, Melynis M, Jakobsen MH, Fallah Z, Spiess K, Hjortø GM, Pui A, Frimurer TM, Rosenkilde MM.
Eur J Med Chem (2018) 155 : 244 -254
PubMed 29886326 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.45 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4163353 2 5.82
CHEMBL4162325 2 5.68
CHEMBL4172689 2 5.52
CHEMBL4175646 2 5.28
CHEMBL4168899 1 5.28
CHEMBL4166498 2 5.02
CHEMBL4169927 2 -
CHEMBL4163068 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4163353 IC50 = 1520.0 nM 5.82
CHEMBL4163353 IC50 = 1513.56 nM 5.82
CHEMBL4162325 IC50 = 2110.0 nM 5.68
CHEMBL4162325 IC50 = 2089.3 nM 5.68
CHEMBL4172689 IC50 = 2990.0 nM 5.52
CHEMBL4172689 IC50 = 3019.95 nM 5.52
CHEMBL4175646 IC50 = 5260.0 nM 5.28
CHEMBL4175646 IC50 = 5248.07 nM 5.28
CHEMBL4168899 IC50 = 5290.0 nM 5.28
CHEMBL4166498 IC50 = 9560.0 nM 5.02
CHEMBL4166498 IC50 = 9549.93 nM 5.02
CHEMBL4169927 IC50 < 10000.0 nM -
CHEMBL4169927 IC50 > 10000.0 nM -
CHEMBL4163068 IC50 > 10000.0 nM -
CHEMBL4163068 IC50 < 10000.0 nM -