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Assay Detail

CHEMBL4155865

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Modulation of basal activity of HCMV US28 delta300 mutant expressed in tetracyclin-induced HEK293 cells assessed as change in inositol phosphate accumulation using [3H]-myo-inositol by scintillation proximity assay
36
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human betaherpesvirus 5
Cell Type HEK293
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Ligand-selective small molecule modulators of the constitutively active vGPCR US28.
Amărandi RM, Lückmann M, Melynis M, Jakobsen MH, Fallah Z, Spiess K, Hjortø GM, Pui A, Frimurer TM, Rosenkilde MM.
Eur J Med Chem (2018) 155 : 244 -254
PubMed 29886326 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 36 5.70 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4162325 2 7.00
CHEMBL4163353 2 6.74
CHEMBL34166 BERLEX COMPOUND 2 6.10
CHEMBL4166498 2 6.10
CHEMBL4159986 2 5.95
CHEMBL4175646 2 5.83
CHEMBL4165476 2 5.82
CHEMBL4162030 2 5.81
CHEMBL4168899 2 5.75
CHEMBL4160964 2 5.50
CHEMBL4174069 2 5.32
CHEMBL4176081 2 5.10
CHEMBL4166806 2 5.00
CHEMBL4177152 2 5.00
CHEMBL4165447 2 4.70
CHEMBL4167806 2 -
CHEMBL4169309 2 -
CHEMBL4176084 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4162325 EC50 = 100.0 nM 7.00
CHEMBL4162325 EC50 = 103.0 nM 6.99
CHEMBL4163353 EC50 = 182.0 nM 6.74
CHEMBL4163353 EC50 = 199.53 nM 6.70
CHEMBL34166 BERLEX COMPOUND EC50 = 794.33 nM 6.10
CHEMBL4166498 EC50 = 794.33 nM 6.10
CHEMBL34166 BERLEX COMPOUND EC50 = 860.0 nM 6.07
CHEMBL4166498 EC50 = 884.0 nM 6.05
CHEMBL4159986 EC50 = 1135.0 nM 5.95
CHEMBL4159986 EC50 = 1258.93 nM 5.90
CHEMBL4175646 EC50 = 1476.0 nM 5.83
CHEMBL4165476 EC50 = 1515.0 nM 5.82
CHEMBL4162030 EC50 = 1563.0 nM 5.81
CHEMBL4175646 EC50 = 1584.89 nM 5.80
CHEMBL4165476 EC50 = 1584.89 nM 5.80
CHEMBL4162030 EC50 = 1584.89 nM 5.80
CHEMBL4168899 EC50 = 1797.0 nM 5.75
CHEMBL4168899 EC50 = 1995.26 nM 5.70
CHEMBL4160964 EC50 = 3162.28 nM 5.50
CHEMBL4160964 EC50 = 3360.0 nM 5.47
CHEMBL4174069 EC50 = 4803.0 nM 5.32
CHEMBL4174069 EC50 = 5011.87 nM 5.30
CHEMBL4176081 EC50 = 7955.0 nM 5.10
CHEMBL4176081 EC50 = 7943.28 nM 5.10
CHEMBL4166806 EC50 = 9880.0 nM 5.00
CHEMBL4166806 EC50 = 10000.0 nM 5.00
CHEMBL4177152 EC50 = 10000.0 nM 5.00
CHEMBL4177152 EC50 = 10982.0 nM 4.96
CHEMBL4165447 EC50 = 19952.62 nM 4.70
CHEMBL4165447 EC50 = 19770.0 nM 4.70
CHEMBL4169309 EC50 > 10000.0 nM -
CHEMBL4169309 EC50 < 10000.0 nM -
CHEMBL4176084 EC50 > 10000.0 nM -
CHEMBL4176084 EC50 < 10000.0 nM -
CHEMBL4167806 EC50 < 10000.0 nM -
CHEMBL4167806 EC50 > 10000.0 nM -