Assay Detail
Binding
CHEMBL4155885
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Inhibition of human FLT3 by Hotspot assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of the selective and efficacious inhibitors of FLT3 mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.73 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163870 | — | — | 1 | 9.72 |
| CHEMBL4172223 | — | — | 1 | 9.33 |
| CHEMBL4075720 | — | — | 1 | 9.22 |
| CHEMBL4164331 | — | — | 1 | 9.21 |
| CHEMBL4175865 | — | — | 1 | 9.19 |
| CHEMBL4171138 | — | — | 1 | 9.18 |
| CHEMBL4159478 | — | — | 1 | 9.18 |
| CHEMBL4160544 | — | — | 1 | 9.14 |
| CHEMBL4160930 | — | — | 1 | 9.02 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.82 |
| CHEMBL4172658 | — | — | 1 | 8.60 |
| CHEMBL4162003 | — | — | 1 | 8.47 |
| CHEMBL4168002 | — | — | 1 | 8.44 |
| CHEMBL4168869 | — | — | 1 | 8.42 |
| CHEMBL4167321 | — | — | 1 | 7.95 |
| CHEMBL4167778 | — | — | 1 | 7.80 |
| CHEMBL4175644 | — | — | 1 | 7.78 |
| CHEMBL4159414 | — | — | 1 | 7.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163870 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4172223 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL4075720 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4164331 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL4175865 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL4171138 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL4159478 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL4160544 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL4160930 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 1.52 | nM | 8.82 |
| CHEMBL4172658 | — | IC50 | = | 2.53 | nM | 8.60 |
| CHEMBL4162003 | — | IC50 | = | 3.42 | nM | 8.47 |
| CHEMBL4168002 | — | IC50 | = | 3.63 | nM | 8.44 |
| CHEMBL4168869 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4167321 | — | IC50 | = | 11.31 | nM | 7.95 |
| CHEMBL4167778 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL4175644 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL4159414 | — | IC50 | = | 20.51 | nM | 7.69 |