Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4155889

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human MV4-11 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Intermediate

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of the selective and efficacious inhibitors of FLT3 mutations.
Zhi Y, Li B, Yao C, Li H, Chen P, Bao J, Qin T, Wang Y, Lu T, Lu S.
Eur J Med Chem (2018) 155 : 303 -315
PubMed 29894944 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.39 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4075720 1 7.80
CHEMBL4163870 1 7.80
CHEMBL4159478 1 7.75
CHEMBL4164331 1 7.72
CHEMBL4172223 1 7.58
CHEMBL4160930 1 7.57
CHEMBL4168869 1 7.48
CHEMBL4171138 1 7.32
CHEMBL4175865 1 7.28
CHEMBL4167321 1 7.24
CHEMBL4172658 1 7.23
CHEMBL4167778 1 7.21
CHEMBL4168002 1 7.21
CHEMBL4160544 1 7.19
CHEMBL4162003 1 7.19
CHEMBL4175644 1 7.11
CHEMBL4159414 1 7.01
CHEMBL4164573 1 -
CHEMBL4172459 1 -
CHEMBL4161156 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4075720 IC50 = 16.0 nM 7.80
CHEMBL4163870 IC50 = 16.0 nM 7.80
CHEMBL4159478 IC50 = 18.0 nM 7.75
CHEMBL4164331 IC50 = 19.0 nM 7.72
CHEMBL4172223 IC50 = 26.0 nM 7.58
CHEMBL4160930 IC50 = 27.0 nM 7.57
CHEMBL4168869 IC50 = 33.0 nM 7.48
CHEMBL4171138 IC50 = 48.0 nM 7.32
CHEMBL4175865 IC50 = 52.0 nM 7.28
CHEMBL4167321 IC50 = 57.0 nM 7.24
CHEMBL4172658 IC50 = 59.0 nM 7.23
CHEMBL4167778 IC50 = 61.0 nM 7.21
CHEMBL4168002 IC50 = 62.0 nM 7.21
CHEMBL4160544 IC50 = 65.0 nM 7.19
CHEMBL4162003 IC50 = 65.0 nM 7.19
CHEMBL4175644 IC50 = 78.0 nM 7.11
CHEMBL4159414 IC50 = 98.0 nM 7.01
CHEMBL4164573 IC50 - -
CHEMBL4172459 IC50 - -
CHEMBL4161156 IC50 - -