Assay Detail
Binding
CHEMBL4155908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human FLT3 F594_R595insREY mutant by Hotspot assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of the selective and efficacious inhibitors of FLT3 mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.29 | 8.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.69 |
| CHEMBL4075720 | — | — | 1 | 8.13 |
| CHEMBL4163870 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 2.03 | nM | 8.69 |
| CHEMBL4075720 | — | IC50 | = | 7.35 | nM | 8.13 |
| CHEMBL4163870 | — | IC50 | = | 9.15 | nM | 8.04 |