Assay Detail
Binding
CHEMBL4155914
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Binding affinity to human FLT3 D835Y mutant (Q580 to Y969 residues) expressed in bacterial expression system by Kinomescan method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of the selective and efficacious inhibitors of FLT3 mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.21 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163870 | — | — | 1 | 8.27 |
| CHEMBL4075720 | — | — | 1 | 8.15 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163870 | — | Kd | = | 5.33 | nM | 8.27 |
| CHEMBL4075720 | — | Kd | = | 7.01 | nM | 8.15 |
| CHEMBL388978 | STAUROSPORINE | Kd | - | — | - |