Assay Detail
Functional
CHEMBL4155960
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Cytotoxicity against human SNU638 cells assessed as decrease in cell viability after 72 hrs by SRB assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-638 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and anticancer activity of fluorocyclopentenyl-purines and - pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.91 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8771 | NEOPLANOCIN A | — | 1 | 6.09 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.97 |
| CHEMBL4169968 | — | — | 1 | 5.64 |
| CHEMBL4166146 | — | — | 1 | 5.52 |
| CHEMBL4172693 | — | — | 1 | 4.56 |
| CHEMBL4164358 | — | — | 1 | 4.50 |
| CHEMBL4169576 | — | — | 1 | 4.49 |
| CHEMBL4175005 | — | — | 1 | 4.15 |
| CHEMBL4169422 | — | — | 1 | 4.08 |
| CHEMBL4164793 | — | — | 1 | 4.06 |
| CHEMBL4159331 | — | — | 1 | - |
| CHEMBL4161653 | — | — | 1 | - |
| CHEMBL4162705 | — | — | 1 | - |
| CHEMBL4176773 | — | — | 1 | - |
| CHEMBL4162426 | — | — | 1 | - |
| CHEMBL4171572 | — | — | 1 | - |
| CHEMBL4160958 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8771 | NEOPLANOCIN A | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4169968 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL4166146 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL4172693 | — | IC50 | = | 27790.0 | nM | 4.56 |
| CHEMBL4164358 | — | IC50 | = | 31970.0 | nM | 4.50 |
| CHEMBL4169576 | — | IC50 | = | 32190.0 | nM | 4.49 |
| CHEMBL4175005 | — | IC50 | = | 70240.0 | nM | 4.15 |
| CHEMBL4169422 | — | IC50 | = | 83650.0 | nM | 4.08 |
| CHEMBL4164793 | — | IC50 | = | 86830.0 | nM | 4.06 |
| CHEMBL4159331 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4161653 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4162705 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4176773 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4162426 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4171572 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4160958 | — | IC50 | > | 100000.0 | nM | - |