Assay Detail
ADMET
CHEMBL4156046
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HHL5 cells assessed as reduction in cell viability after 24 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
N-phenylsulfonyl-3,5-bis(arylidene)-4-piperidone derivatives as activation NF-κB inhibitors in hepatic carcinoma cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.85 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.03 |
| CHEMBL4170124 | — | — | 1 | 4.96 |
| CHEMBL4166261 | — | — | 1 | 4.96 |
| CHEMBL4173579 | — | — | 1 | 4.95 |
| CHEMBL4168203 | — | — | 1 | 4.95 |
| CHEMBL4162806 | — | — | 1 | 4.95 |
| CHEMBL4163272 | — | — | 1 | 4.92 |
| CHEMBL4160285 | — | — | 1 | 4.91 |
| CHEMBL4176873 | — | — | 1 | 4.89 |
| CHEMBL4166712 | — | — | 1 | 4.88 |
| CHEMBL4165653 | — | — | 1 | 4.87 |
| CHEMBL4167872 | — | — | 1 | 4.87 |
| CHEMBL4159952 | — | — | 1 | 4.87 |
| CHEMBL4170550 | — | — | 1 | 4.86 |
| CHEMBL4164441 | — | — | 1 | 4.85 |
| CHEMBL4177342 | — | — | 1 | 4.84 |
| CHEMBL4175079 | — | — | 1 | 4.81 |
| CHEMBL4161740 | — | — | 1 | 4.80 |
| CHEMBL4169672 | — | — | 1 | 4.80 |
| CHEMBL4173077 | — | — | 1 | 4.75 |
| CHEMBL4173985 | — | — | 1 | 4.75 |
| CHEMBL4159901 | — | — | 1 | 4.74 |
| CHEMBL4165172 | — | — | 1 | 4.72 |
| CHEMBL4162212 | — | — | 1 | 4.72 |
| CHEMBL4173511 | — | — | 1 | 4.70 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 9270.0 | nM | 5.03 |
| CHEMBL4170124 | — | IC50 | = | 11020.0 | nM | 4.96 |
| CHEMBL4166261 | — | IC50 | = | 11070.0 | nM | 4.96 |
| CHEMBL4173579 | — | IC50 | = | 11190.0 | nM | 4.95 |
| CHEMBL4168203 | — | IC50 | = | 11330.0 | nM | 4.95 |
| CHEMBL4162806 | — | IC50 | = | 11270.0 | nM | 4.95 |
| CHEMBL4163272 | — | IC50 | = | 11940.0 | nM | 4.92 |
| CHEMBL4160285 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4176873 | — | IC50 | = | 12860.0 | nM | 4.89 |
| CHEMBL4166712 | — | IC50 | = | 13260.0 | nM | 4.88 |
| CHEMBL4165653 | — | IC50 | = | 13420.0 | nM | 4.87 |
| CHEMBL4167872 | — | IC50 | = | 13482.0 | nM | 4.87 |
| CHEMBL4159952 | — | IC50 | = | 13630.0 | nM | 4.87 |
| CHEMBL4170550 | — | IC50 | = | 13770.0 | nM | 4.86 |
| CHEMBL4164441 | — | IC50 | = | 14160.0 | nM | 4.85 |
| CHEMBL4177342 | — | IC50 | = | 14410.0 | nM | 4.84 |
| CHEMBL4175079 | — | IC50 | = | 15330.0 | nM | 4.81 |
| CHEMBL4161740 | — | IC50 | = | 16010.0 | nM | 4.80 |
| CHEMBL4169672 | — | IC50 | = | 15930.0 | nM | 4.80 |
| CHEMBL4173077 | — | IC50 | = | 17810.0 | nM | 4.75 |
| CHEMBL4173985 | — | IC50 | = | 17770.0 | nM | 4.75 |
| CHEMBL4159901 | — | IC50 | = | 18130.0 | nM | 4.74 |
| CHEMBL4165172 | — | IC50 | = | 19040.0 | nM | 4.72 |
| CHEMBL4162212 | — | IC50 | = | 19170.0 | nM | 4.72 |
| CHEMBL4173511 | — | IC50 | = | 20020.0 | nM | 4.70 |
| CHEMBL140 | CURCUMIN | IC50 | = | 22270.0 | nM | 4.65 |