Assay Detail
Functional
CHEMBL4156140
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Antiparasitic activity against promastigote form of Leishmania amazonensis MHOM/BR/Josefa assessed as parasite growth inhibition after 72 hrs by Neubauer hemocytometer
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania amazonensis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Symmetrical and unsymmetrical substituted 2,5-diarylidene cyclohexanones as anti-parasitic compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.13 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.22 |
| CHEMBL476455 | — | — | 1 | 5.64 |
| CHEMBL4165781 | — | — | 1 | 5.58 |
| CHEMBL274993 | 2,6-DIBENZYLIDENECYCLOHEXANONE | — | 1 | 5.55 |
| CHEMBL474918 | — | — | 1 | 5.44 |
| CHEMBL4177472 | — | — | 1 | 5.43 |
| CHEMBL1951553 | — | — | 1 | 5.41 |
| CHEMBL477057 | — | — | 1 | 5.39 |
| CHEMBL475523 | — | — | 1 | 5.38 |
| CHEMBL477256 | — | — | 1 | 5.37 |
| CHEMBL4170254 | — | — | 1 | 5.35 |
| CHEMBL478481 | — | — | 1 | 5.34 |
| CHEMBL4170345 | — | — | 1 | 5.33 |
| CHEMBL4173699 | — | — | 1 | 5.32 |
| CHEMBL4169216 | — | — | 1 | 5.31 |
| CHEMBL4160574 | — | — | 1 | 5.28 |
| CHEMBL4175287 | — | — | 1 | 5.24 |
| CHEMBL4166258 | — | — | 1 | 5.05 |
| CHEMBL4175677 | — | — | 1 | 5.05 |
| CHEMBL4162333 | — | — | 1 | 5.00 |
| CHEMBL4165057 | — | — | 1 | 4.97 |
| CHEMBL4162803 | — | — | 1 | 4.93 |
| CHEMBL4174563 | — | — | 1 | 4.89 |
| CHEMBL4167411 | — | — | 1 | 4.78 |
| CHEMBL387599 | — | — | 1 | 4.77 |
| CHEMBL4168483 | — | — | 1 | 4.76 |
| CHEMBL4169962 | — | — | 1 | 4.75 |
| CHEMBL4160745 | — | — | 1 | 4.70 |
| CHEMBL4171844 | — | — | 1 | 4.70 |
| CHEMBL1571795 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL476455 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4165781 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL274993 | 2,6-DIBENZYLIDENECYCLOHEXANONE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL474918 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4177472 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1951553 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL477057 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL475523 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL477256 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4170254 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL478481 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4170345 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4173699 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4169216 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4160574 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4175287 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4175677 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4166258 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4162333 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4165057 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4162803 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4174563 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4167411 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL387599 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4168483 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4169962 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4160745 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4171844 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL1571795 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL482410 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL1904137 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL4170741 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL183244 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL140 | CURCUMIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL4162393 | — | IC50 | > | 100000.0 | nM | - |