Assay Detail
Binding
CHEMBL4156482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of fungal FcyB expressed in Aspergillus nidulans assessed as reduction in FcyB-mediated [2,8-3H]-adenine accumulation
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Fungi |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships in fungal nucleobases transporters as dissected by the inhibitory effects of novel purine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 4.51 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3906124 | — | — | 1 | 5.30 |
| CHEMBL226345 | ADENINE | 3.0 | 1 | 5.16 |
| CHEMBL1427 | HYPOXANTHINE | — | 1 | 4.96 |
| CHEMBL4172784 | — | — | 1 | 4.72 |
| CHEMBL3907630 | — | — | 1 | 4.42 |
| CHEMBL4177224 | — | — | 1 | 4.38 |
| CHEMBL4168319 | — | — | 1 | 4.31 |
| CHEMBL4166601 | — | — | 1 | 4.14 |
| CHEMBL4170440 | — | — | 1 | 4.13 |
| CHEMBL4170020 | — | — | 1 | 4.09 |
| CHEMBL4173873 | — | — | 1 | 4.00 |
| CHEMBL4176165 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3906124 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL226345 | ADENINE | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL1427 | HYPOXANTHINE | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL4172784 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL3907630 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL4177224 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL4168319 | — | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL4166601 | — | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL4170440 | — | Ki | = | 74000.0 | nM | 4.13 |
| CHEMBL4170020 | — | Ki | = | 82000.0 | nM | 4.09 |
| CHEMBL4173873 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL4176165 | — | Ki | = | 106000.0 | nM | - |