Assay Detail
Binding
CHEMBL4156509
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Binding affinity to recombinant full-length human carbonic anhydrase 2 expressed in Escherichia coli assessed as intrinsic Kd in presence of ANS by fluorescent thermal shift assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 29 | 9.57 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4176862 | — | — | 1 | 10.96 |
| CHEMBL4170371 | — | — | 1 | 10.74 |
| CHEMBL4168966 | — | — | 1 | 10.66 |
| CHEMBL4163518 | — | — | 1 | 10.46 |
| CHEMBL4173471 | — | — | 1 | 10.16 |
| CHEMBL4159066 | — | — | 1 | 9.96 |
| CHEMBL4166643 | — | — | 1 | 9.85 |
| CHEMBL4165570 | — | — | 1 | 9.85 |
| CHEMBL4165543 | — | — | 1 | 9.85 |
| CHEMBL4160149 | — | — | 1 | 9.80 |
| CHEMBL4162451 | — | — | 1 | 9.54 |
| CHEMBL4170058 | — | — | 1 | 9.43 |
| CHEMBL4176828 | — | — | 1 | 9.43 |
| CHEMBL4165896 | — | — | 1 | 9.41 |
| CHEMBL4168997 | — | — | 1 | 9.36 |
| CHEMBL4160627 | — | — | 1 | 9.35 |
| CHEMBL120886 | — | — | 1 | 9.33 |
| CHEMBL4166964 | — | — | 1 | 9.32 |
| CHEMBL4175740 | — | — | 1 | 9.28 |
| CHEMBL4162133 | — | — | 1 | 9.28 |
| CHEMBL4177268 | — | — | 1 | 9.25 |
| CHEMBL4172331 | — | — | 1 | 9.24 |
| CHEMBL4174214 | — | — | 1 | 9.10 |
| CHEMBL4168586 | — | — | 1 | 9.08 |
| CHEMBL4165127 | — | — | 1 | 9.04 |
| CHEMBL4173501 | — | — | 1 | 8.92 |
| CHEMBL4173814 | — | — | 1 | 8.80 |
| CHEMBL4161701 | — | — | 1 | 8.51 |
| CHEMBL4170792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4176862 | — | Kd | = | 0.011 | nM | 10.96 |
| CHEMBL4170371 | — | Kd | = | 0.018 | nM | 10.74 |
| CHEMBL4168966 | — | Kd | = | 0.022 | nM | 10.66 |
| CHEMBL4163518 | — | Kd | = | 0.035 | nM | 10.46 |
| CHEMBL4173471 | — | Kd | = | 0.069 | nM | 10.16 |
| CHEMBL4159066 | — | Kd | = | 0.11 | nM | 9.96 |
| CHEMBL4166643 | — | Kd | = | 0.14 | nM | 9.85 |
| CHEMBL4165570 | — | Kd | = | 0.14 | nM | 9.85 |
| CHEMBL4165543 | — | Kd | = | 0.14 | nM | 9.85 |
| CHEMBL4160149 | — | Kd | = | 0.16 | nM | 9.80 |
| CHEMBL4162451 | — | Kd | = | 0.29 | nM | 9.54 |
| CHEMBL4170058 | — | Kd | = | 0.37 | nM | 9.43 |
| CHEMBL4176828 | — | Kd | = | 0.37 | nM | 9.43 |
| CHEMBL4165896 | — | Kd | = | 0.39 | nM | 9.41 |
| CHEMBL4168997 | — | Kd | = | 0.44 | nM | 9.36 |
| CHEMBL4160627 | — | Kd | = | 0.45 | nM | 9.35 |
| CHEMBL120886 | — | Kd | = | 0.47 | nM | 9.33 |
| CHEMBL4166964 | — | Kd | = | 0.48 | nM | 9.32 |
| CHEMBL4175740 | — | Kd | = | 0.53 | nM | 9.28 |
| CHEMBL4162133 | — | Kd | = | 0.52 | nM | 9.28 |
| CHEMBL4177268 | — | Kd | = | 0.56 | nM | 9.25 |
| CHEMBL4172331 | — | Kd | = | 0.58 | nM | 9.24 |
| CHEMBL4174214 | — | Kd | = | 0.8 | nM | 9.10 |
| CHEMBL4168586 | — | Kd | = | 0.84 | nM | 9.08 |
| CHEMBL4165127 | — | Kd | = | 0.92 | nM | 9.04 |
| CHEMBL4173501 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL4173814 | — | Kd | = | 1.6 | nM | 8.80 |
| CHEMBL4161701 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL4170792 | — | Kd | = | 0.006 | nM | - |