Assay Detail
Binding
CHEMBL4156516
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Binding affinity to recombinant human carbonic anhydrase 9 (38 to 414 residues) expressed in 293-F cells assessed as intrinsic Kd in presence of ANS by fluorescent thermal shift assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 29 | 9.62 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4176828 | — | — | 1 | 10.96 |
| CHEMBL4174214 | — | — | 1 | 10.96 |
| CHEMBL4160627 | — | — | 1 | 10.72 |
| CHEMBL4177268 | — | — | 1 | 10.60 |
| CHEMBL4166643 | — | — | 1 | 10.00 |
| CHEMBL4173471 | — | — | 1 | 9.66 |
| CHEMBL4160149 | — | — | 1 | 9.60 |
| CHEMBL4166964 | — | — | 1 | 9.44 |
| CHEMBL4165570 | — | — | 1 | 9.40 |
| CHEMBL4168997 | — | — | 1 | 9.37 |
| CHEMBL4175740 | — | — | 1 | 9.23 |
| CHEMBL120886 | — | — | 1 | 9.22 |
| CHEMBL4162133 | — | — | 1 | 9.19 |
| CHEMBL4165896 | — | — | 1 | 9.16 |
| CHEMBL4172331 | — | — | 1 | 9.13 |
| CHEMBL4173814 | — | — | 1 | 9.11 |
| CHEMBL4165127 | — | — | 1 | 9.05 |
| CHEMBL4168586 | — | — | 1 | 8.96 |
| CHEMBL4173501 | — | — | 1 | 8.96 |
| CHEMBL4170371 | — | — | 1 | - |
| CHEMBL4162451 | — | — | 1 | - |
| CHEMBL4159066 | — | — | 1 | - |
| CHEMBL4176862 | — | — | 1 | - |
| CHEMBL4163518 | — | — | 1 | - |
| CHEMBL4170792 | — | — | 1 | - |
| CHEMBL4165543 | — | — | 1 | - |
| CHEMBL4170058 | — | — | 1 | - |
| CHEMBL4168966 | — | — | 1 | - |
| CHEMBL4161701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4176828 | — | Kd | = | 0.011 | nM | 10.96 |
| CHEMBL4174214 | — | Kd | = | 0.011 | nM | 10.96 |
| CHEMBL4160627 | — | Kd | = | 0.019 | nM | 10.72 |
| CHEMBL4177268 | — | Kd | = | 0.025 | nM | 10.60 |
| CHEMBL4166643 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL4173471 | — | Kd | = | 0.22 | nM | 9.66 |
| CHEMBL4160149 | — | Kd | = | 0.25 | nM | 9.60 |
| CHEMBL4166964 | — | Kd | = | 0.36 | nM | 9.44 |
| CHEMBL4165570 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL4168997 | — | Kd | = | 0.43 | nM | 9.37 |
| CHEMBL4175740 | — | Kd | = | 0.59 | nM | 9.23 |
| CHEMBL120886 | — | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL4162133 | — | Kd | = | 0.65 | nM | 9.19 |
| CHEMBL4165896 | — | Kd | = | 0.69 | nM | 9.16 |
| CHEMBL4172331 | — | Kd | = | 0.74 | nM | 9.13 |
| CHEMBL4173814 | — | Kd | = | 0.77 | nM | 9.11 |
| CHEMBL4165127 | — | Kd | = | 0.89 | nM | 9.05 |
| CHEMBL4168586 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL4173501 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL4170371 | — | Kd | = | 0.008 | nM | - |
| CHEMBL4162451 | — | Kd | - | — | - | |
| CHEMBL4159066 | — | Kd | = | 0.0057 | nM | - |
| CHEMBL4176862 | — | Kd | = | 0.004 | nM | - |
| CHEMBL4163518 | — | Kd | = | 0.007 | nM | - |
| CHEMBL4170792 | — | Kd | = | 0.006 | nM | - |
| CHEMBL4165543 | — | Kd | = | 0.004 | nM | - |
| CHEMBL4170058 | — | Kd | - | — | - | |
| CHEMBL4168966 | — | Kd | = | 0.007 | nM | - |
| CHEMBL4161701 | — | Kd | - | — | - |