Assay Detail
Binding
CHEMBL4156517
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human carbonic anhydrase 12 (30 to 291 residues) expressed in Escherichia coli Rosetta 2 (DE3) strain assessed as intrinsic Kd in presence of ANS by fluorescent thermal shift assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 27 | 9.40 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165543 | — | — | 1 | 10.89 |
| CHEMBL4177268 | — | — | 1 | 10.64 |
| CHEMBL4170792 | — | — | 1 | 10.51 |
| CHEMBL4168966 | — | — | 1 | 10.39 |
| CHEMBL4170371 | — | — | 1 | 10.11 |
| CHEMBL4176862 | — | — | 1 | 10.09 |
| CHEMBL4163518 | — | — | 1 | 10.09 |
| CHEMBL4168586 | — | — | 1 | 9.68 |
| CHEMBL4166643 | — | — | 1 | 9.68 |
| CHEMBL4160627 | — | — | 1 | 9.51 |
| CHEMBL4160149 | — | — | 1 | 9.47 |
| CHEMBL4159066 | — | — | 1 | 9.29 |
| CHEMBL4168997 | — | — | 1 | 9.29 |
| CHEMBL4175740 | — | — | 1 | 9.18 |
| CHEMBL4172331 | — | — | 1 | 9.12 |
| CHEMBL120886 | — | — | 1 | 9.12 |
| CHEMBL4165570 | — | — | 1 | 9.12 |
| CHEMBL4165896 | — | — | 1 | 9.07 |
| CHEMBL4173471 | — | — | 1 | 9.00 |
| CHEMBL4170058 | — | — | 1 | 9.00 |
| CHEMBL4165127 | — | — | 1 | 8.92 |
| CHEMBL4166964 | — | — | 1 | 8.85 |
| CHEMBL4162133 | — | — | 1 | 8.62 |
| CHEMBL4173814 | — | — | 1 | 8.57 |
| CHEMBL4174214 | — | — | 1 | 8.11 |
| CHEMBL4173501 | — | — | 1 | 8.00 |
| CHEMBL4161701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165543 | — | Kd | = | 0.013 | nM | 10.89 |
| CHEMBL4177268 | — | Kd | = | 0.023 | nM | 10.64 |
| CHEMBL4170792 | — | Kd | = | 0.031 | nM | 10.51 |
| CHEMBL4168966 | — | Kd | = | 0.041 | nM | 10.39 |
| CHEMBL4170371 | — | Kd | = | 0.077 | nM | 10.11 |
| CHEMBL4176862 | — | Kd | = | 0.081 | nM | 10.09 |
| CHEMBL4163518 | — | Kd | = | 0.081 | nM | 10.09 |
| CHEMBL4168586 | — | Kd | = | 0.21 | nM | 9.68 |
| CHEMBL4166643 | — | Kd | = | 0.21 | nM | 9.68 |
| CHEMBL4160627 | — | Kd | = | 0.31 | nM | 9.51 |
| CHEMBL4160149 | — | Kd | = | 0.34 | nM | 9.47 |
| CHEMBL4159066 | — | Kd | = | 0.51 | nM | 9.29 |
| CHEMBL4168997 | — | Kd | = | 0.51 | nM | 9.29 |
| CHEMBL4175740 | — | Kd | = | 0.66 | nM | 9.18 |
| CHEMBL4172331 | — | Kd | = | 0.75 | nM | 9.12 |
| CHEMBL120886 | — | Kd | = | 0.76 | nM | 9.12 |
| CHEMBL4165570 | — | Kd | = | 0.75 | nM | 9.12 |
| CHEMBL4165896 | — | Kd | = | 0.85 | nM | 9.07 |
| CHEMBL4173471 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL4170058 | — | Kd | = | 0.99 | nM | 9.00 |
| CHEMBL4165127 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL4166964 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL4162133 | — | Kd | = | 2.4 | nM | 8.62 |
| CHEMBL4173814 | — | Kd | = | 2.7 | nM | 8.57 |
| CHEMBL4174214 | — | Kd | = | 7.7 | nM | 8.11 |
| CHEMBL4173501 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4161701 | — | Kd | - | — | - |