Assay Detail
Binding
CHEMBL4156519
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Binding affinity to recombinant N-terminal His6-tagged human carbonic anhydrase 14 (20 to 280 residues) expressed in Escherichia coli Rosetta2 (DE3) strain assessed as intrinsic Kd in presence of ANS by fluorescent thermal shift assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 29 | 9.73 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170371 | — | — | 1 | 11.00 |
| CHEMBL4170792 | — | — | 1 | 10.92 |
| CHEMBL4163518 | — | — | 1 | 10.46 |
| CHEMBL4165543 | — | — | 1 | 10.33 |
| CHEMBL4162451 | — | — | 1 | 10.29 |
| CHEMBL4160627 | — | — | 1 | 10.11 |
| CHEMBL4165570 | — | — | 1 | 10.09 |
| CHEMBL4166643 | — | — | 1 | 10.00 |
| CHEMBL4174214 | — | — | 1 | 9.96 |
| CHEMBL4177268 | — | — | 1 | 9.57 |
| CHEMBL4166964 | — | — | 1 | 9.57 |
| CHEMBL4168997 | — | — | 1 | 9.52 |
| CHEMBL4175740 | — | — | 1 | 9.52 |
| CHEMBL4160149 | — | — | 1 | 9.47 |
| CHEMBL4170058 | — | — | 1 | 9.43 |
| CHEMBL4173471 | — | — | 1 | 9.42 |
| CHEMBL4172331 | — | — | 1 | 9.40 |
| CHEMBL4165896 | — | — | 1 | 9.40 |
| CHEMBL4173501 | — | — | 1 | 9.40 |
| CHEMBL4168586 | — | — | 1 | 9.35 |
| CHEMBL120886 | — | — | 1 | 9.27 |
| CHEMBL4162133 | — | — | 1 | 9.15 |
| CHEMBL4165127 | — | — | 1 | 9.01 |
| CHEMBL4173814 | — | — | 1 | 8.96 |
| CHEMBL4159066 | — | — | 1 | - |
| CHEMBL4176862 | — | — | 1 | - |
| CHEMBL4168966 | — | — | 1 | - |
| CHEMBL4176828 | — | — | 1 | - |
| CHEMBL4161701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170371 | — | Kd | = | 0.01 | nM | 11.00 |
| CHEMBL4170792 | — | Kd | = | 0.012 | nM | 10.92 |
| CHEMBL4163518 | — | Kd | = | 0.035 | nM | 10.46 |
| CHEMBL4165543 | — | Kd | = | 0.047 | nM | 10.33 |
| CHEMBL4162451 | — | Kd | = | 0.051 | nM | 10.29 |
| CHEMBL4160627 | — | Kd | = | 0.077 | nM | 10.11 |
| CHEMBL4165570 | — | Kd | = | 0.081 | nM | 10.09 |
| CHEMBL4166643 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL4174214 | — | Kd | = | 0.11 | nM | 9.96 |
| CHEMBL4177268 | — | Kd | = | 0.27 | nM | 9.57 |
| CHEMBL4166964 | — | Kd | = | 0.27 | nM | 9.57 |
| CHEMBL4168997 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL4175740 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL4160149 | — | Kd | = | 0.34 | nM | 9.47 |
| CHEMBL4170058 | — | Kd | = | 0.37 | nM | 9.43 |
| CHEMBL4173471 | — | Kd | = | 0.38 | nM | 9.42 |
| CHEMBL4172331 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL4165896 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL4173501 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL4168586 | — | Kd | = | 0.45 | nM | 9.35 |
| CHEMBL120886 | — | Kd | = | 0.54 | nM | 9.27 |
| CHEMBL4162133 | — | Kd | = | 0.71 | nM | 9.15 |
| CHEMBL4165127 | — | Kd | = | 0.984 | nM | 9.01 |
| CHEMBL4173814 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL4159066 | — | Kd | = | 0.0094 | nM | - |
| CHEMBL4176862 | — | Kd | = | 0.004 | nM | - |
| CHEMBL4168966 | — | Kd | = | 0.005 | nM | - |
| CHEMBL4176828 | — | Kd | - | — | - | |
| CHEMBL4161701 | — | Kd | - | — | - |