Assay Detail
Functional
CHEMBL4156646
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Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and screening of 1, 2, 4-triazinone derivatives as potential antitumor agents with apoptosis inducing activity on MCF-7 breast cancer cell line.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.34 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4174756 | — | — | 1 | 6.46 |
| CHEMBL4160802 | — | — | 1 | 6.44 |
| CHEMBL4161876 | — | — | 1 | 6.39 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 5.66 |
| CHEMBL4172196 | — | — | 1 | 5.54 |
| CHEMBL4169404 | — | — | 1 | 5.51 |
| CHEMBL4175930 | — | — | 1 | 5.50 |
| CHEMBL4172526 | — | — | 1 | 5.48 |
| CHEMBL4163580 | — | — | 1 | 5.36 |
| CHEMBL4171004 | — | — | 1 | 5.27 |
| CHEMBL4174870 | — | — | 1 | 5.17 |
| CHEMBL4161582 | — | — | 1 | 5.05 |
| CHEMBL4171801 | — | — | 1 | 5.02 |
| CHEMBL4176940 | — | — | 1 | 4.87 |
| CHEMBL4168845 | — | — | 1 | 4.77 |
| CHEMBL4162755 | — | — | 1 | 4.71 |
| CHEMBL4168731 | — | — | 1 | 4.54 |
| CHEMBL4168723 | — | — | 1 | 4.42 |
| CHEMBL4165312 | — | — | 1 | - |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4174756 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4160802 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4161876 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL61 | PODOFILOX | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL4172196 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL4169404 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL4175930 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL4172526 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL4163580 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL4171004 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL4174870 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL4161582 | — | IC50 | = | 8970.0 | nM | 5.05 |
| CHEMBL4171801 | — | IC50 | = | 9490.0 | nM | 5.02 |
| CHEMBL4176940 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4168845 | — | IC50 | = | 16830.0 | nM | 4.77 |
| CHEMBL4162755 | — | IC50 | = | 19420.0 | nM | 4.71 |
| CHEMBL4168731 | — | IC50 | = | 28540.0 | nM | 4.54 |
| CHEMBL4168723 | — | IC50 | = | 38340.0 | nM | 4.42 |
| CHEMBL4165312 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44657 | ETOPOSIDE | IC50 | - | — | - |