Assay Detail
Functional
CHEMBL4156811
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CXCR4 in human CCRF-CEM cells assessed as inhibition of SDF-1alpha-induced calcium release preincubated for 25 mins followed by SDF-1alpha stimulation and measured for 90 secs by calcium flux assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.39 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4173977 | — | — | 1 | 8.54 |
| CHEMBL4162609 | — | — | 1 | 8.45 |
| CHEMBL4159234 | — | — | 1 | 8.35 |
| CHEMBL4172669 | — | — | 1 | 8.22 |
| CHEMBL3091687 | — | — | 1 | 8.20 |
| CHEMBL4163874 | — | — | 1 | 7.86 |
| CHEMBL4170542 | — | — | 1 | 7.85 |
| CHEMBL4169280 | — | — | 1 | 7.83 |
| CHEMBL4176701 | — | — | 1 | 7.79 |
| CHEMBL4171755 | — | — | 1 | 7.77 |
| CHEMBL4169875 | — | — | 1 | 7.75 |
| CHEMBL4163467 | — | — | 1 | 7.68 |
| CHEMBL4161589 | — | — | 1 | 7.67 |
| CHEMBL4167324 | — | — | 1 | 7.63 |
| CHEMBL4171365 | — | — | 1 | 7.60 |
| CHEMBL4165854 | — | — | 1 | 7.57 |
| CHEMBL4168391 | — | — | 1 | 7.53 |
| CHEMBL4167145 | — | — | 1 | 7.51 |
| CHEMBL4166059 | — | — | 1 | 7.50 |
| CHEMBL4177130 | — | — | 1 | 7.49 |
| CHEMBL4164970 | — | — | 1 | 7.47 |
| CHEMBL4160496 | — | — | 1 | 7.21 |
| CHEMBL4169504 | — | — | 1 | 7.04 |
| CHEMBL4175596 | — | — | 1 | 6.84 |
| CHEMBL4176403 | — | — | 1 | 6.81 |
| CHEMBL4177338 | — | — | 1 | 6.77 |
| CHEMBL4172898 | — | — | 1 | 6.71 |
| CHEMBL4162011 | — | — | 1 | 6.50 |
| CHEMBL4173777 | — | — | 1 | 6.44 |
| CHEMBL4175201 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4173977 | — | IC50 | = | 2.92 | nM | 8.54 |
| CHEMBL4162609 | — | IC50 | = | 3.59 | nM | 8.45 |
| CHEMBL4159234 | — | IC50 | = | 4.47 | nM | 8.35 |
| CHEMBL4172669 | — | IC50 | = | 6.08 | nM | 8.22 |
| CHEMBL3091687 | — | IC50 | = | 6.25 | nM | 8.20 |
| CHEMBL4163874 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL4170542 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL4169280 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL4176701 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL4171755 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL4169875 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL4163467 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL4161589 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL4167324 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL4171365 | — | IC50 | = | 25.2 | nM | 7.60 |
| CHEMBL4165854 | — | IC50 | = | 26.7 | nM | 7.57 |
| CHEMBL4168391 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL4167145 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL4166059 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4177130 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL4164970 | — | IC50 | = | 33.9 | nM | 7.47 |
| CHEMBL4160496 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4169504 | — | IC50 | = | 91.2 | nM | 7.04 |
| CHEMBL4175596 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4176403 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4177338 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL4172898 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4162011 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL4173777 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL4175201 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL4168418 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL4166081 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4176285 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL4161949 | — | IC50 | > | 16700.0 | nM | - |