Assay Detail
Binding
CHEMBL4157380
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Inhibition of refolded MDH (unknown origin) preincubated with Escherichia coli GroEL/GroES for 45 mins using sodium mesoxalate as substrate by spectrometric analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.39 | 4.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4167333 | — | — | 1 | 4.47 |
| CHEMBL4161583 | — | — | 1 | 4.43 |
| CHEMBL4169499 | — | — | 1 | 4.40 |
| CHEMBL4176697 | — | — | 1 | 4.37 |
| CHEMBL4162794 | — | — | 1 | 4.28 |
| CHEMBL4166077 | — | — | 1 | - |
| CHEMBL4168023 | — | — | 1 | - |
| CHEMBL4160098 | — | — | 1 | - |
| CHEMBL4161487 | — | — | 1 | - |
| CHEMBL3975683 | — | — | 1 | - |
| CHEMBL3970551 | — | — | 1 | - |
| CHEMBL3955935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4167333 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4161583 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4169499 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4176697 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4162794 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL4166077 | — | IC50 | > | 63000.0 | nM | - |
| CHEMBL4168023 | — | IC50 | > | 63000.0 | nM | - |
| CHEMBL4160098 | — | IC50 | > | 63000.0 | nM | - |
| CHEMBL4161487 | — | IC50 | > | 63000.0 | nM | - |
| CHEMBL3975683 | — | IC50 | > | 63000.0 | nM | - |
| CHEMBL3970551 | — | IC50 | > | 63000.0 | nM | - |
| CHEMBL3955935 | — | IC50 | > | 63000.0 | nM | - |