Assay Detail
Binding
CHEMBL4157622
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of MPEP from mGluR5 (unknown origin) after 3 hrs by liquid scintillation counting method
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.55 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239800 | FENOBAM ANHYDROUS | 2.0 | 2 | 7.50 |
| CHEMBL4166199 | — | — | 1 | 5.72 |
| CHEMBL4167825 | — | — | 1 | 5.51 |
| CHEMBL4171187 | — | — | 1 | - |
| CHEMBL4160584 | — | — | 1 | - |
| CHEMBL4174628 | — | — | 1 | - |
| CHEMBL4163974 | — | — | 1 | - |
| CHEMBL4164391 | — | — | 1 | - |
| CHEMBL4172276 | — | — | 1 | - |
| CHEMBL4175689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239800 | FENOBAM ANHYDROUS | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL239800 | FENOBAM ANHYDROUS | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL4166199 | — | Ki | = | 1883.0 | nM | 5.72 |
| CHEMBL4167825 | — | Ki | = | 3077.0 | nM | 5.51 |
| CHEMBL4171187 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4160584 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4174628 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4163974 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4164391 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4172276 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4175689 | — | Ki | - | — | - |