Assay Detail
Functional
CHEMBL4157891
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Antioxidant activity assessed as protection against ferrous ions and dioxygen-induced free radical-mediated DNA strand break in pEMBL8 supercoiled DNA preincubated with DNA followed by (NH4)2Fe(SO4)2.6H2O addition measured after 6 mins by ethidium bromide staining based agarose gel electrophoresis method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel heteroring-annulated pyrrolino-tetrahydroberberine analogues as antioxidant agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.12 | 4.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4175741 | — | — | 1 | 4.20 |
| CHEMBL4172332 | — | — | 1 | 4.13 |
| CHEMBL275097 | TETRAHYDROBERBERINE | — | 1 | 4.03 |
| CHEMBL4161450 | — | — | 1 | - |
| CHEMBL4169377 | — | — | 1 | - |
| CHEMBL4161702 | — | — | 1 | - |
| CHEMBL4165128 | — | — | 1 | - |
| CHEMBL4168549 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4175741 | — | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL4172332 | — | EC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL275097 | TETRAHYDROBERBERINE | EC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL4161450 | — | EC50 | = | 683000.0 | nM | - |
| CHEMBL4169377 | — | EC50 | = | 407000.0 | nM | - |
| CHEMBL4161702 | — | EC50 | = | 119000.0 | nM | - |
| CHEMBL4165128 | — | EC50 | = | 196000.0 | nM | - |
| CHEMBL4168549 | — | EC50 | = | 140000.0 | nM | - |