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Assay Detail

CHEMBL4158217

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MMP12 (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Macrophage metalloelastase (CHEMBL4393)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study.
Fuerst R, Yong Choi J, Knapinska AM, Smith L, Cameron MD, Ruiz C, Fields GB, Roush WR.
Bioorg Med Chem (2018) 26 : 4984 -4995
PubMed 30249495 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.75 5.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4080520 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4080520 IC50 = 1800.0 nM 5.75