Assay Detail
Binding
CHEMBL4158631
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 4 subunit alpha (CHEMBL2072) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.07 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170712 | — | — | 1 | 7.64 |
| CHEMBL4159473 | — | — | 1 | 7.64 |
| CHEMBL4167379 | — | — | 1 | 7.43 |
| CHEMBL4160074 | — | — | 1 | 7.41 |
| CHEMBL4160943 | — | — | 1 | 7.28 |
| CHEMBL4169884 | — | — | 1 | 7.28 |
| CHEMBL4174312 | — | — | 1 | 7.14 |
| CHEMBL4163637 | — | — | 1 | 7.05 |
| CHEMBL4162835 | — | — | 1 | 7.04 |
| CHEMBL4167720 | — | — | 1 | 6.99 |
| CHEMBL4159169 | — | — | 1 | 6.98 |
| CHEMBL4174592 | — | — | 1 | 6.93 |
| CHEMBL4164272 | — | — | 1 | 6.84 |
| CHEMBL4163942 | — | — | 1 | 6.79 |
| CHEMBL4175995 | — | — | 1 | 6.75 |
| CHEMBL4167083 | — | — | 1 | 6.74 |
| CHEMBL4175589 | — | — | 1 | 6.71 |
| CHEMBL4168880 | — | — | 1 | 6.59 |
| CHEMBL4171314 | — | — | 1 | - |
| CHEMBL4175832 | — | — | 1 | - |
| CHEMBL4167979 | — | — | 1 | - |
| CHEMBL4172428 | — | — | 1 | - |
| CHEMBL4164545 | — | — | 1 | - |
| CHEMBL4159239 | — | — | 1 | - |
| CHEMBL4160718 | — | — | 1 | - |
| CHEMBL4174769 | — | — | 1 | - |
| CHEMBL4170776 | — | — | 1 | - |
| CHEMBL4171687 | — | — | 1 | - |
| CHEMBL4175203 | — | — | 1 | - |
| CHEMBL4165596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170712 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4159473 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4167379 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4160074 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4160943 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4169884 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4174312 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4163637 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4162835 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4167720 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL4159169 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4174592 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4164272 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4163942 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4175995 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL4167083 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL4175589 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL4168880 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL4171314 | — | IC50 | - | — | - | |
| CHEMBL4175832 | — | IC50 | - | — | - | |
| CHEMBL4167979 | — | IC50 | - | — | - | |
| CHEMBL4172428 | — | IC50 | - | — | - | |
| CHEMBL4164545 | — | IC50 | - | — | - | |
| CHEMBL4159239 | — | IC50 | - | — | - | |
| CHEMBL4160718 | — | IC50 | - | — | - | |
| CHEMBL4174769 | — | IC50 | - | — | - | |
| CHEMBL4170776 | — | IC50 | - | — | - | |
| CHEMBL4171687 | — | IC50 | - | — | - | |
| CHEMBL4175203 | — | IC50 | - | — | - | |
| CHEMBL4165596 | — | IC50 | - | — | - | |
| CHEMBL4174202 | — | IC50 | - | — | - | |
| CHEMBL4164121 | — | IC50 | - | — | - | |
| CHEMBL4165380 | — | IC50 | - | — | - |