Assay Detail
Binding
CHEMBL4158634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nav1.8 expressed in HEK293 cells after 10 mins by patchxpress-based electrophysiology
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 10 subunit alpha (CHEMBL5451) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.29 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4169884 | — | — | 1 | 6.29 |
| CHEMBL4164272 | — | — | 1 | - |
| CHEMBL4159169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4169884 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL4164272 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4159169 | — | IC50 | > | 1000.0 | nM | - |